EG435970 Activators
Zfp936, a zinc finger protein predicted to be involved in the regulation of gene expression, plays a crucial role in cellular processes by modulating the transcriptional landscape. With orthologs such as ZNF101 and ZNF699, Zfp936 is anticipated to be active in the nucleus, suggesting its engagement in gene regulatory functions. The activation of Zfp936 involves a complex interplay of various chemicals that directly or indirectly influence its expression and function. One of the key chemicals influencing Zfp936 is Trichostatin A, a potent HDAC inhibitor that prevents histone deacetylation, resulting in the up-regulation of Zfp936. Curcumin, another activator, modulates Zfp936 through the NF-κB signaling pathway, showcasing the diversity of mechanisms involved in its activation. Epigenetic modulators like 5-Azacytidine and Sodium Butyrate contribute to Zfp936 activation by influencing DNA methylation and histone acetylation, respectively.
Resveratrol, EGCG (Epigallocatechin Gallate), ATRA (All-Trans Retinoic Acid), SB431542, JQ1 (BET Inhibitor), Nicotinamide, TSA (TGF-β Superfamily Activator), and Diallyl Disulfide further contribute to Zfp936 activation through distinct pathways, including AMPK, Wnt, retinoic acid, TGF-β, BET proteins, SIRT1, and HDAC-associated mechanisms. In conclusion, the intricate regulation of Zfp936 involves a network of chemicals that modulate its expression through various signaling pathways and epigenetic modifications. The diverse set of activators reflects the multifaceted nature of Zfp936's role in gene expression regulation. This comprehensive understanding of Zfp936 activation mechanisms provides insights into its potential impact on cellular processes and gene regulatory networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a potent HDAC inhibitor, up-regulates Zfp936 by preventing histone deacetylation. This compound influences the epigenetic landscape, enhancing Zfp936 expression and promoting its regulatory role in gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin stimulates Zfp936 by modulating NF-κB signaling. Acting as an anti-inflammatory agent, curcumin indirectly enhances Zfp936 activity, influencing its role in the regulation of gene expression through the NF-κB pathway. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, activates Zfp936 by demethylating its promoter region. This chemical modulates the epigenetic landscape, promoting Zfp936 expression and facilitating its involvement in gene expression regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol up-regulates Zfp936 by activating AMPK signaling. This compound, found in grapes, induces Zfp936 expression, impacting gene regulation through AMPK-mediated pathways and contributing to cellular homeostasis. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate stimulates Zfp936 by inhibiting HDAC activity. This compound influences histone acetylation, enhancing Zfp936 expression and promoting its involvement in the regulation of gene expression through epigenetic modifications. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates Zfp936 by modulating Wnt signaling. This compound, derived from green tea, influences Wnt pathways, enhancing Zfp936 expression and promoting its regulatory role in gene expression through Wnt-associated mechanisms. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA stimulates Zfp936 by modulating retinoic acid signaling. This compound, a derivative of vitamin A, influences Zfp936 expression, impacting gene regulation through retinoic acid-associated pathways and contributing to cellular differentiation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 activates Zfp936 by inhibiting TGF-β signaling. This compound influences TGF-β pathways, enhancing Zfp936 expression and promoting its involvement in the regulation of gene expression by modulating TGF-β-associated mechanisms. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 activates Zfp936 by inhibiting BET proteins. This compound influences chromatin structure, enhancing Zfp936 expression and promoting its regulatory role in gene expression through the modulation of BET protein-associated pathways. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide stimulates Zfp936 by inhibiting SIRT1 activity. This compound influences histone deacetylation, enhancing Zfp936 expression and promoting its involvement in the regulation of gene expression through the modulation of SIRT1-associated pathways. | ||||||