E030010N08Rik Activators
Crocc2, a member of the rootletin family, is integral to cellular functions and is expressed prominently in various tissues, including the central nervous system, dorsal root ganglion, embryo mesenchyme, and lung. As a ciliary rootlet coiled-coil protein, Crocc2 likely plays a crucial role in the organization and maintenance of ciliary structures, contributing to cellular processes in diverse tissues. The activation of Crocc2 involves a complex interplay of signaling pathways influenced by various chemicals. These chemicals act directly or indirectly on Crocc2 expression, modulating its levels in different tissues. For instance, retinoic acid directly up-regulates Crocc2 by binding to retinoic acid receptors, enhancing its transcription and subsequent expression in the embryo mesenchyme. Indirect activators, such as forskolin and PMA, modulate cAMP/PKA and PKC signaling, respectively, influencing Crocc2 expression in tissues like the dorsal root ganglion.
Understanding the activation mechanisms of Crocc2 sheds light on its functional significance, particularly in ciliary structure and cellular organization. The intricate interplay of chemicals influencing various signaling pathways underscores the complex regulatory network governing Crocc2 expression. Further exploration of the specific roles of Crocc2 in diverse tissues promises to deepen our understanding of its contributions to cellular structure and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Indirectly activates Crocc2 by inhibiting GSK3β, promoting Wnt signaling. This influences the expression of Crocc2 in the central nervous system and dorsal root ganglion. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Indirectly up-regulates Crocc2 by inhibiting HDACs, facilitating histone acetylation, and promoting transcriptional activation in tissues like the lung. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates PKC, indirectly influencing Crocc2 expression by modulating signaling pathways in the central nervous system and dorsal root ganglion. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Directly up-regulates Crocc2 by binding to retinoic acid receptors, enhancing gene transcription and promoting its expression in the embryo mesenchyme. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits TGF-β receptor, indirectly promoting Crocc2 expression by modulating signaling pathways in tissues like the lung. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Indirectly enhances Crocc2 expression by inhibiting HDACs, promoting histone acetylation, and facilitating transcriptional activation in the central nervous system. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Induces calcium influx, indirectly promoting Crocc2 expression through calmodulin-dependent processes in tissues like the lung. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, indirectly activating Crocc2 by disrupting PI3K/Akt signaling, influencing gene expression in the embryo mesenchyme. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Activates calcium signaling pathways, indirectly influencing Crocc2 expression through calmodulin-dependent processes in the central nervous system. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Indirectly activates Crocc2 by inhibiting BRD4, relieving transcriptional repression, and promoting its expression in tissues like the dorsal root ganglion. | ||||||