E030010N08Rik Inhibitors
Crocc2, an ortholog of human CROCC2, emerges as a pivotal player in cellular processes, exhibiting expression in the central nervous system, dorsal root ganglion, embryo mesenchyme, and lung. As a member of the ciliary rootlet coiled-coil family, Crocc2 is integral to the assembly and maintenance of ciliary rootlets-a structural component essential for various cellular functions. Ciliary rootlets are specialized cytoskeletal structures emanating from the base of cilia, acting as scaffolds that provide mechanical support and contribute to the stability of the ciliary apparatus. These structures are particularly crucial for ciliary function, which includes roles in signal transduction, cellular signaling pathways, and mechanosensation.
The inhibition of Crocc2 involves a spectrum of chemical agents that directly or indirectly impact its function. Direct inhibitors, such as microtubule-stabilizing or -depolymerizing agents, directly interfere with Crocc2 by modulating microtubule dynamics. Given the role of Crocc2 in ciliary rootlet assembly, disruptions in microtubule stability profoundly affect the structural integrity of ciliary rootlets. Indirect inhibitors influence Crocc2 through pathways crucial for ciliary rootlet formation. For instance, compounds targeting TGF-β receptors or PI3K/AKT signaling pathways impact Crocc2 expression or function indirectly by modulating these signaling cascades. Similarly, inhibitors affecting chromatin structure or cell cycle progression impact Crocc2 transcriptionally or post-translationally, demonstrating the multifaceted regulation of this ciliary rootlet coiled-coil protein. The diverse mechanisms of inhibition underscore the intricate regulatory network governing Crocc2 and its involvement in fundamental cellular processes. The interconnectedness of Crocc2 with microtubule dynamics, cell cycle events, and signaling pathways highlights its significance in orchestrating ciliary rootlet assembly. Understanding the nuances of Crocc2 function and inhibition provides valuable insights into the broader landscape of ciliary biology and its role in cellular homeostasis. The intricate interplay of these chemical inhibitors with Crocc2-related structures contributes to the foundational knowledge necessary for unraveling the complexities of ciliary rootlet biology and its implications in various tissues and developmental contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Microtubule-stabilizing agent impacting mitotic spindle dynamics. Directly inhibits Crocc2 by stabilizing microtubules, preventing proper ciliary rootlet formation. The disruption of microtubule dynamics interferes with the assembly and maintenance of Crocc2-related structures, leading to inhibition. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Microtubule-depolymerizing agent affecting spindle assembly. Directly inhibits Crocc2 by disrupting microtubule dynamics, hindering ciliary rootlet formation. The interference with microtubule structure prevents the proper assembly and function of Crocc2-related structures, resulting in inhibition. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Microtubule-depolymerizing agent impacting spindle assembly. Directly inhibits Crocc2 by disrupting microtubule dynamics, impeding ciliary rootlet formation. Altered microtubule structure interferes with the proper assembly and maintenance of Crocc2-related structures, leading to inhibition. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
PLK1 inhibitor affecting mitotic progression. Directly inhibits Crocc2 by disrupting PLK1-mediated phosphorylation events crucial for ciliary rootlet formation. Impaired phosphorylation impacts the assembly and maintenance of Crocc2-related structures, resulting in inhibition. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β receptor inhibitor affecting signaling. Indirectly inhibits Crocc2 by modulating TGF-β pathway, impacting ciliary rootlet formation. Altered TGF-β signaling influences the expression and function of Crocc2, leading to inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor affecting the PI3K/AKT pathway. Indirectly inhibits Crocc2 by modulating a signaling pathway crucial for ciliary rootlet formation. Altered PI3K/AKT signaling may influence Crocc2 expression or function, providing a potential indirect mechanism of inhibition. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Myosin II inhibitor affecting actin dynamics. Indirectly inhibits Crocc2 by disrupting actin-related processes crucial for ciliary rootlet formation. Altered actin dynamics impact the assembly and maintenance of Crocc2-related structures, resulting in inhibition. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor affecting protein degradation. Indirectly inhibits Crocc2 by preventing proteasomal degradation of critical components for ciliary rootlet formation. Altered protein turnover influences the assembly and maintenance of Crocc2-related structures, leading to inhibition. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor affecting chromatin structure. Indirectly inhibits Crocc2 by modulating gene expression crucial for ciliary rootlet formation. Altered chromatin structure influences the transcriptional regulation of Crocc2, impacting its expression and function, resulting in inhibition. | ||||||
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
CDK1 inhibitor affecting cell cycle progression. Directly inhibits Crocc2 by disrupting CDK1-mediated phosphorylation events crucial for ciliary rootlet formation. Impaired phosphorylation impacts the assembly and maintenance of Crocc2-related structures, resulting in inhibition. | ||||||