Molecular structure of RO-3306, CAS Number: 872573-93-8
RO-3306 (CAS 872573-93-8)
See product citations (37)
Alternate Names:
5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Application:
RO-3306 is an inhibitor of CDK1/cyclin B1 and CDK1/cyclin A
CAS Number:
872573-93-8
Purity:
≥95%
Molecular Weight:
351.44
Molecular Formula:
C18H13N3OS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RO-3306 may act to inhibit CDK1/cyclin B1 and CDK1/cyclin A. It also inhibits CDK2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and serum- and glucocorticoid-induce kinase (Ki = 497 nM) but not CDK4.1. It reversibly arrests human cells at the G2/M border of the cell cycle and allows for effective cell synchronization without the use of microtubule poisons in early mitosis. Prolonged treatment of cells with RO-3306 induces apoptosis and this can be augmented in acute myeloid leukemia cells by stimulating p53 activity with nutlin-3.3. In other words, RO-3306 actively enhances downstream p53 signaling to promote apoptosis.
RO-3306 (CAS 872573-93-8) References
- Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. | Vassilev, LT., et al. 2006. Proc Natl Acad Sci U S A. 103: 10660-5. PMID: 16818887
- Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1. | Vassilev, LT. 2006. Cell Cycle. 5: 2555-6. PMID: 17172841
- Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. | Kojima, K., et al. 2009. Cancer Sci. 100: 1128-36. PMID: 19385969
- Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. | Johnson, N., et al. 2011. Nat Med. 17: 875-82. PMID: 21706030
- HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. | Deardorff, MA., et al. 2012. Nature. 489: 313-7. PMID: 22885700
- Are Orai1 and Orai3 channels more important than calcium influx for cell proliferation? | Borowiec, AS., et al. 2014. Biochim Biophys Acta. 1843: 464-72. PMID: 24321771
- A specific inhibitor of CDK1, RO-3306, reversibly arrests meiosis during in vitro maturation of porcine oocytes. | Jang, WI., et al. 2014. Anim Reprod Sci. 144: 102-8. PMID: 24374180
- Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis. | Czaplinski, S., et al. 2016. Oncotarget. 7: 8700-11. PMID: 26046302
- RO-3306 prevents postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro. | Prasad, S., et al. 2016. Biomed Pharmacother. 78: 216-225. PMID: 26898445
- Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306. | Zhou, X., et al. 2016. J Control Release. 234: 90-7. PMID: 27212103
- Accumulation of cytoplasmic Cdk1 is associated with cancer growth and survival rate in epithelial ovarian cancer. | Yang, W., et al. 2016. Oncotarget. 7: 49481-49497. PMID: 27385216
- CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner. | Prevo, R., et al. 2018. Cell Cycle. 17: 1513-1523. PMID: 30045664
- CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity. | Sunada, S., et al. 2021. Biochem Biophys Res Commun. 550: 56-61. PMID: 33684621
- Relation between Vitamin D Level and Cyclin-Dependent Kinase-1 Gene Expression in Egyptian Patients with Lupus Nephritis and their Impact on Disease Activity. | Osman, EMA., et al. 2021. Indian J Nephrol. 31: 163-168. PMID: 34267439
- The CDK1 inhibitor, Ro-3306, is a potential antiviral candidate against influenza virus infection. | Zhao, L., et al. 2022. Antiviral Res. 201: 105296. PMID: 35367281
Inhibitor of:
4930404A10Rik, APC13, APC15, BC024659, Cdc28, Cdk1, Cdk1/Cdk2, CLASP (Cytoplasmic Linker Associated Protein), Clb3, cyclin A, cyclin B1, cyclin G2, cyclin Y, D2Bwg1423e, D4Wsu53e, DCAMKL3, E030010N08Rik, E2F-7, EG215895, EG633057, fzr, HRT1_Hrt1, IDAS, kleisin β, Lambda 5, MIS12, Mitotic Cells, Ninein, PCTAIRE-3, Pericentrin 2, PHLDB2, Phox2b, PRDM11, STK31, TFIIH p89, TRAP230, Tropomyosin γ, TTC14, VRK1, VRK3, WAPL, ZFP260, and Zfp874.Activator of:
BUB3, BUBR1, C10orf104, CEP135, Chfr, CUL-5, Dullard, KIF15, Kizuna_Plk1s1, MER3, MZT1, Septin 3, SFI1, Sgo2, SMC4, Sororin, Spc25, and TP53INP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RO-3306, 1 mg | sc-358700 | 1 mg | $66.00 | |||
RO-3306, 5 mg | sc-358700A | 5 mg | $163.00 | |||
RO-3306, 25 mg | sc-358700B | 25 mg | $326.00 |