Dnmt2 Inhibitors
The class of Dnmt2 Inhibitors consists of chemicals that can indirectly hinder the activity of Dnmt2, a unique methyltransferase known for its role in tRNA methylation. These inhibitors primarily act through mechanisms that disrupt the methylation process or alter the availability of substrates and co-factors necessary for Dnmt2's enzymatic function. For example, nucleoside analogs like Azacitidine and Decitabine, traditionally known for targeting DNA methyltransferases, may exert off-target effects on Dnmt2. They incorporate into RNA and DNA, potentially disrupting the normal methylation patterns that Dnmt2 would usually mediate.
Other compounds, such as Hydralazine and Procainamide, known for their primary pharmacological actions, also exhibit DNA methylation inhibitory properties. These effects could extend to the methylation processes involving tRNA, thereby indirectly affecting Dnmt2 activity. RG108, a non-nucleoside DNA methyltransferase inhibitor, and EGCG, a polyphenol from green tea, have been shown to modulate epigenetic states and could have implications for Dnmt2 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog of cytidine that incorporates into RNA and DNA and inhibits DNA methyltransferases, potentially affecting Dnmt2's tRNA methylation activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Another nucleoside analog that targets DNA methyltransferases, could indirectly affect Dnmt2 activity by altering methylation patterns. | ||||||
1-Hydrazinophthalazine Hydrochloride | 304-20-1 | sc-206167 | 10 g | $280.00 | ||
A vasodilator that can also inhibit DNA methylation, potentially influencing Dnmt2 activity indirectly. | ||||||
Procainamide hydrochloride | 614-39-1 | sc-202297 | 10 g | $53.00 | ||
An antiarrhythmic agent, known to act as a DNA methylation inhibitor, could indirectly affect Dnmt2. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, which might have off-target effects influencing Dnmt2's tRNA methylation activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, known for its ability to modulate epigenetic states, potentially affecting Dnmt2. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Used for chronic alcoholism; shown to have DNA methyltransferase inhibitory activity, which might indirectly affect Dnmt2. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
A product of S-Adenosyl Methionine-dependent methylation reactions; can act as a potent inhibitor of methyltransferase enzymes, potentially affecting Dnmt2. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Known to inhibit sirtuins; its broader effects on cellular metabolism could potentially influence Dnmt2 activity. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
A flavonoid that can modulate various cellular processes including epigenetic mechanisms, potentially impacting Dnmt2 activity. | ||||||