Molecular structure of Fisetin, CAS Number: 528-48-3
Fisetin (CAS 528-48-3)
See product citations (7)
Alternate Names:
3,3′,4′,7-Tetrahydroxyflavone
Application:
Fisetin is a potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent
CAS Number:
528-48-3
Purity:
≥96%
Molecular Weight:
286.24
Molecular Formula:
C15H10O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fisetin is a flavone which acts as an inhibitor of Akt, Cdk6, mTOR and PI 3-kinase and an activator of ERK. It may act to inhibit melanoma cell growth via its mTOR binding activity. Fisetin exhibits a high affinity for DNA binding, effectively inhibiting transcriptional activity by blocking the binding of RNA polymerase II. Furthermore, it demonstrates the ability to inhibit hydrogen peroxide-induced lipid peroxidation in vitro.
Fisetin (CAS 528-48-3) References
- Fisetin ameliorates oxidative glutamate testicular toxicity in rats via central and peripheral mechanisms involving SIRT1 activation. | Rizk, FH., et al. 2022. Redox Rep. 27: 177-185. PMID: 36047349
- The effects of fisetin on bone and cartilage: A systematic review. | Yamaura, K., et al. 2022. Pharmacol Res. 185: 106504. PMID: 36243333
- Fisetin Ameliorates Alcohol-Induced Liver Injury through Regulating SIRT1 and SphK1 Pathway. | Zhou, ZS., et al. 2022. Am J Chin Med. 50: 2171-2184. PMID: 36266756
- The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress. | Hassan, SSU., et al. 2022. Front Pharmacol. 13: 1015835. PMID: 36299900
- Fisetin Attenuates Arsenic-Induced Hepatic Damage by Improving Biochemical, Inflammatory, Apoptotic, and Histological Profile: In Vivo and In Silico Approach. | Umar, M., et al. 2022. Evid Based Complement Alternat Med. 2022: 1005255. PMID: 36310620
- Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy. | Ma, P., et al. 2022. Int J Pharm X. 4: 100138. PMID: 36405872
- A novel 4'-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/STAT3 pathways in non-small-cell lung cancer without any adverse effects in mice. | Sabarwal, A., et al. 2022. FASEB J. 36: e22654. PMID: 36421014
- The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment. | Rahmani, AH., et al. 2022. Molecules. 27: PMID: 36558146
- Effects of Fisetin, a Plant-Derived Flavonoid, on Response to Oxidative Stress, Aging, and Age-Related Diseases in Caenorhabditis elegans. | Park, S., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36558979
- Fisetin, a dietary flavonoid, increases the sensitivity of chemoresistant head and neck carcinoma cells to cisplatin possibly through HSP90AA1/IL-17 pathway. | Ling, J., et al. 2023. Phytother Res.. PMID: 36631292
- Fisetin alleviates cellular senescence through PTEN mediated inhibition of PKCΔ-NOX1 pathway in vascular smooth muscle cells. | Kim, SG., et al. 2023. Arch Gerontol Geriatr. 108: 104927. PMID: 36645971
- The Effects of Fisetin on Cyclosporine-Treated Dry Eye Disease in Dogs. | Krajčíková, K., et al. 2023. Int J Mol Sci. 24: PMID: 36675005
- Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation. | Roy, T., et al. 2022. Front Immunol. 13: 1075804. PMID: 36741386
- Fisetin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF. | Lai, M., et al. 2023. J Ophthalmol. 2023: 7951928. PMID: 36777991
Inhibitor of:
5-LO, ADAR2, Akt, Angptl4, AP1S1, BLVRB, c-Fos, C/EBP ζ, CBP β, CCL28, Cdk6, CYP1B1, Dnmt2, Factor H, Fc ε RIγ, FLTR3, FN3K, GAGE10, Galactose Mutarotase, Glucose-6-Phosphate Dehydrogenase, GPD2, HIV-1 Gag, HuC, IGFBP1, Ivl, LOX, mTOR, NAT-14, PANK2, PI 3-kinase, Pim-2, PRC1, PRMT7, Psg29, RAO, RDH8, resistin-like γ, RFT1, RGD1304773, RUNX1, SA-1, Ser/Thr Protein Kinase, SHOX2A, SIP1, SLC43A1, Spi-B, SULT2A2, SULT2A7, SV40 T Ag, Tas2r102, Tas2r114, Tas2r140, Tas2r143, TEX24, TLR12, TMPRSS11E2, TYW1B, V1RC24, V1RC25, V1RC32, V1rc5, Vitrin, Ythdc1, ZNF527, and ZNF737.Activator of:
A20, ASCC2, B7-H3, BC026590, BDNF, C5, CALHM3, casein kinase IIα′, CD40L, Centrin-2, CKIP-1, Cyp2c69, DBC1, Dectin-2, DNA pol ε ss, DnaJB2, DnaJC28, DUOX1, DUSP5, Dynactin 6, EG434396, EMILIN-5, ERK, FMNL3, FNDC7, FRG2C, Glut8, Histone cluster 1 H4I, Histone cluster 1 H4K, HLTF, I2PP2A, IFN-γR2, IL-13Rα1, IRS-1, Klk1b3, LOC100039269, LOC100041019, Ly6G6e, Mast Cell Protease 8, MBIP, Measles M, MGST1, Myt 1, NAGLU, NALP9A, NDUFB11, Nurr1, P2P-R, PI 3-kinase p110γ, PIF1, PSMD5, resistin, RGS13, ROGDI, S19BP, Sir2, SIRT1, SIRT2, SIRT4, SIRT5, SULT2A1, TBC1D8B, TEN1, TFB2M, TFIIH p44, TIP30, Tryptase ε, USP29, V3R 3, VEGI, Vitronectin, ZNF267, and ZNF581.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fisetin, 50 mg | sc-276440 | 50 mg | $51.00 | |||
Fisetin, 100 mg | sc-276440A | 100 mg | $77.00 | |||
Fisetin, 500 mg | sc-276440B | 500 mg | $102.00 | |||
Fisetin, 1 g | sc-276440C | 1 g | $153.00 | |||
Fisetin, 100 g | sc-276440D | 100 g | $2856.00 |