Dnmt2 Inhibitors

The class of Dnmt2 Inhibitors consists of chemicals that can indirectly hinder the activity of Dnmt2, a unique methyltransferase known for its role in tRNA methylation. These inhibitors primarily act through mechanisms that disrupt the methylation process or alter the availability of substrates and co-factors necessary for Dnmt2's enzymatic function. For example, nucleoside analogs like Azacitidine and Decitabine, traditionally known for targeting DNA methyltransferases, may exert off-target effects on Dnmt2. They incorporate into RNA and DNA, potentially disrupting the normal methylation patterns that Dnmt2 would usually mediate.

Other compounds, such as Hydralazine and Procainamide, known for their primary pharmacological actions, also exhibit DNA methylation inhibitory properties. These effects could extend to the methylation processes involving tRNA, thereby indirectly affecting Dnmt2 activity. RG108, a non-nucleoside DNA methyltransferase inhibitor, and EGCG, a polyphenol from green tea, have been shown to modulate epigenetic states and could have implications for Dnmt2 activity.