DBC1 Activators
DBC1 Activators encompass a diverse group of chemical compounds known for their ability to directly enhance the functional activity of the DBC1 protein. DBC1, or Deleted in Breast Cancer 1, is a crucial player in cellular processes involving DNA repair, apoptosis, and gene expression regulation. One notable activator within this class is Resveratrol, a natural polyphenol. Resveratrol acts by modulating the SIRT1 pathway. It effectively activates SIRT1, a deacetylase enzyme that targets DBC1. As a result of this activation, SIRT1 deacetylates DBC1, increasing its binding affinity for various protein partners. This enhanced interaction amplifies DBC1's role in DNA repair mechanisms and apoptotic pathways. Quercetin, a flavonoid, indirectly activates DBC1 by inhibiting CD38, an enzyme that consumes NAD+. This inhibition leads to elevated cellular NAD+ levels, further stimulating SIRT1, which promotes DBC1 deacetylation, strengthening its participation in DNA damage repair and gene expression control.
Another member of the DBC1 Activators is Nicotinamide, which has a unique mechanism. Nicotinamide inhibits SIRT1, causing an accumulation of acetylated DBC1. Surprisingly, this acetylation increase makes DBC1 a more effective inhibitor of other proteins like PARP1 involved in DNA repair processes. These DBC1 Activators, by influencing DBC1's interactions within specific cellular pathways, offer valuable tools to enhance DBC1's functional activity. They play a pivotal role in maintaining genomic integrity, regulating gene expression, and promoting efficient DNA repair, all of which are essential processes for cellular health and survival.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Enhances DBC1 activity by activating the SIRT1 pathway, leading to increased DNA repair and apoptosis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Indirectly activates DBC1 by inhibiting CD38, raising cellular NAD+ levels, and promoting SIRT1-mediated DBC1 deacetylation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Influences DBC1 by inhibiting SIRT1, resulting in increased acetylation and enhanced inhibition of proteins like PARP1 in DNA repair. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Activates DBC1 through various pathways, including SIRT1 activation and direct interaction, enhancing its role in DNA damage response and gene regulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Boosts DBC1 activity via Nrf2 activation, leading to the upregulation of DBC1 expression and subsequent involvement in DNA repair processes. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
Enhances DBC1 by providing cofactors for SIRT1, leading to DBC1 deacetylation and stronger interactions with partner proteins in DNA repair. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $56.00 $71.00 $124.00 | 7 | |
Indirectly activates DBC1 by increasing cellular NAD+ levels through the inhibition of CD38, promoting SIRT1-mediated DBC1 deacetylation. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Activates DBC1 through SIRT1 activation, resulting in enhanced DBC1 participation in DNA repair and gene expression regulation. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Enhances DBC1 by modulating SIRT1 activity, increasing DBC1 deacetylation, and promoting its involvement in DNA damage response pathways. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Activates DBC1 by inducing DNA damage, leading to the recruitment of DBC1 to sites of DNA lesions and enhancing its role in DNA repair. | ||||||