DACH2 Inhibitors
DACH2 inhibitors are a class of chemical compounds designed to target and inhibit the function of the DACH2 protein, which is part of the Dachshund family of transcription factors. DACH2 plays a significant role in regulating gene expression by influencing transcriptional activity through its interactions with DNA and other transcriptional regulators. It is involved in a variety of biological processes, including developmental pathways, cell differentiation, and gene regulatory networks. By inhibiting DACH2, these compounds disrupt its ability to regulate specific genes, leading to changes in transcriptional activity that can affect downstream cellular processes.
The development of DACH2 inhibitors relies on a detailed understanding of the protein's structural domains, especially its DNA-binding regions and sites where it interacts with co-regulatory proteins. These inhibitors are typically designed to either prevent DACH2 from binding to its target DNA sequences or to block its interactions with other proteins that facilitate its transcriptional regulatory functions. High-throughput screening, molecular modeling, and biochemical assays are commonly used to identify and refine inhibitors with high specificity and potency against DACH2. By selectively inhibiting DACH2, these compounds provide a means to modulate the transcriptional programs governed by this protein, offering insights into the broader regulatory mechanisms that control gene expression and cell behavior. The study of DACH2 inhibition can reveal important information about transcriptional regulation, protein-DNA interactions, and the intricate signaling networks that underlie cellular development and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could hypothetically cause hypomethylation of the DACH2 gene's promoter region, which may lead to transcriptional repression and a consequent decrease in DACH2 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
By inhibiting DNA methyltransferase activity, 5-Aza-2′-Deoxycytidine may specifically lead to the demethylation of the DACH2 promoter, culminating in the downregulation of DACH2 synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Potentially, Trichostatin A could increase histone acetylation around the DACH2 gene, causing chromatin to become more condensed and thereby repressing DACH2 transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid might target histone deacetylases, leading to altered histone acetylation near the DACH2 gene and subsequent transcriptional repression of DACH2. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A could competitively inhibit transcription factor binding to DNA regions critical for DACH2 expression, leading to a decrease in DACH2 protein levels. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
By specifically targeting DNA methyltransferases, RG 108 could promote the demethylation of the DACH2 gene, which may result in decreased transcription and lower DACH2 levels. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As an inhibitor of tyrosine kinases, Genistein might disrupt signaling pathways that control the transcription of DACH2, potentially leading to downregulation of DACH2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
This polyphenolic compound may inhibit the expression of DACH2 by interfering with signaling pathways or transcription factors necessary for DACH2 gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might downregulate DACH2 expression by altering the chromatin structure around the DACH2 gene, leading to tighter chromatin packing and reduced transcriptional activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram could indirectly lead to the downregulation of DACH2 expression by inhibiting enzymes involved in post-translational modifications that stabilize transcription factors regulating DACH2. | ||||||