Dab1 Inhibitors
Dab1 inhibitors are a class of chemicals that reduce the functional activity of Dab1, a protein involved in the Reelin pathway that plays a critical role in the regulation of neuronal migration during brain development. These inhibitors exert their effects by influencing the biochemical pathways that directly regulate the activity of Dab1. U0126 and PD98059 are MEK1/2 inhibitors that reduce the phosphorylation of ERK1/2 in the MAPK pathway, thereby reducing the activation of Dab1. LY294002 and Wortmannin are PI3K inhibitors that reduce the activation of Akt, leading to a decrease in the phosphorylation and activation of Dab1. Rapamycin is an mTOR inhibitor that also reduces the activation of Akt, leading to a decrease in the phosphorylation and activation of Dab1. PP2 is an inhibitor of Src family kinases, which are direct upstream regulators of Dab1. By inhibiting these kinases, PP2 reduces the phosphorylation and activation of Dab1.
SB203580 and SP600125 are inhibitors of p38 MAPK and JNK respectively, both part of the MAPK pathway. Their inhibition reduces the activation of Dab1, which functions downstream of this pathway. BAY 11-7082 and PDTC are inhibitors of NF-κB activation. Dab1 has been found to interact with components of the NF-κB pathway, and so its phosphorylation and activation can be reduced by these inhibitors. AG 490 and Stattic are inhibitors of the JAK2/STAT pathway, with Dab1 known to interact with components of this pathway. These inhibitors consequently suppress the phosphorylation and activation of Dab1. It's important to note that these inhibitors do not act on Dab1 directly, but rather they exert their effects on the upstream regulators of Dab1. By inhibiting these upstream components, the downstream effects on Dab1 can be controlled. This underlines the complex interplay of biochemical pathways and the possibility of modulating a particular protein's function by influencing its upstream regulators.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which is an upstream regulator of the Akt pathway. Dab1 has been found to be an Akt substrate and the inhibition of PI3K by LY294002 can reduce the phosphorylation and activation of Dab1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K, which is an upstream regulator of the Akt pathway. As an Akt substrate, the activation of Dab1 can be reduced by the inhibition of PI3K by Wortmannin. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK1/2, which are upstream regulators of ERK1/2 in the MAPK pathway. By inhibiting these kinases, PD98059 can reduce the phosphorylation and activation of Dab1, which functions downstream of MAPK. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR, which is an upstream regulator of the Akt pathway. As Dab1 is an Akt substrate, the inhibition of mTOR by Rapamycin can reduce the phosphorylation and activation of Dab1. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family kinases. Dab1 is a substrate of Src family kinases and the inhibition of these kinases by PP2 can reduce the phosphorylation and activation of Dab1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. Dab1 is known to function downstream of the MAPK pathway and the inhibition of p38 MAPK by SB203580 can reduce the phosphorylation and activation of Dab1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the MAPK pathway. By inhibiting JNK, SP600125 can reduce the phosphorylation and activation of Dab1, which functions downstream of MAPK. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation. Dab1 has been found to interact with components of the NF-κB pathway and the inhibition of this pathway by BAY 11-7082 can reduce the phosphorylation and activation of Dab1. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC is an inhibitor of NF-κB activation. As Dab1 has been found to interact with components of the NF-κB pathway, the inhibition of this pathway by PDTC can reduce the phosphorylation and activation of Dab1. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 (AG 490) is an inhibitor of the Janus kinase 2 (JAK2)/STAT pathway. Dab1 has been found to interact with components of the JAK2/STAT pathway and the inhibition of this pathway by AG 490 can reduce the phosphorylation and activation of Dab1. | ||||||