Dab1 Activators
Dab1 activators are a class of chemicals that enhance the functional activity of Dab1, a protein involved in the Reelin pathway that plays a critical role in the regulation of neuronal migration during brain development. These activators exert their effects by influencing the biochemical pathways that directly regulate the activity of Dab1. Insulin and LPA are examples of activators that enhance the phosphorylation of Dab1 by activating PI3K, an upstream regulator of the Akt pathway in which Dab1 is a substrate. Similarly, EGF and Trastuzumab enhance the phosphorylation of Dab1 by activating EGFR and HER2/neu receptors respectively, which are upstream regulators of the MAPK pathway in which Dab1 functions downstream.
Another class of Dab1 activators, including Bradykinin, Epinephrine, and Prostaglandin E2, enhance Dab1 activity by simultaneously activating both PI3K/Akt and MAPK pathways, thereby influencing Dab1 which resides downstream in these pathways. In contrast, other activators like Nicotinic acid, Leptin, Angiotensin II, and Glucagon activate the PI3K/Akt pathway by binding to their respective receptors, subsequently enhancing the phosphorylation and activation of Dab1. VEGF, a well-known vascular endothelial growth factor, activates the VEGFR, which can stimulate both PI3K/Akt and MAPK pathways to enhance the functional activity of Dab1. The detailed interactions of these activators with their receptors and subsequent pathways indicate a diverse range of mechanisms through which the activity of Dab1 can be enhanced.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates PI3K, which is an upstream regulator of the Akt pathway. Dab1 is an Akt substrate, and the activation of PI3K by insulin can enhance the phosphorylation and activation of Dab1. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA activates LPAR, which can stimulate the PI3K/Akt pathway. As Dab1 is an Akt substrate, the activation of PI3K/Akt pathway by LPA can enhance the phosphorylation and activation of Dab1. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates the B2 receptor, which can stimulate both the PI3K/Akt and MAPK pathways. As Dab1 is an Akt substrate and functions downstream of MAPK, the activation of these pathways by Bradykinin can enhance the phosphorylation and activation of Dab1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates the β-adrenergic receptor, which can stimulate the PI3K/Akt pathway. As Dab1 is an Akt substrate, the activation of the PI3K/Akt pathway by Epinephrine can enhance the phosphorylation and activation of Dab1. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic acid activates the GPR109A receptor, which can stimulate the PI3K/Akt pathway. As Dab1 is an Akt substrate, the activation of the PI3K/Akt pathway by Nicotinic acid can enhance the phosphorylation and activation of Dab1. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Ob (hBA-147) activates the leptin receptor, which can stimulate the PI3K/Akt pathway. As Dab1 is an Akt substrate, the activation of PI3K/Akt pathway by Leptin can enhance the phosphorylation and activation of Dab1. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II activates the AT1 receptor, which can stimulate the PI3K/Akt pathway. As Dab1 is an Akt substrate, the activation of the PI3K/Akt pathway by Angiotensin II can enhance the phosphorylation and activation of Dab1. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 activates the EP2 receptor, which can stimulate both the PI3K/Akt and MAPK pathways. As Dab1 is an Akt substrate and functions downstream of MAPK, the activation of these pathways by Prostaglandin E2 can enhance the phosphorylation and activation of Dab1. | ||||||