Lysophosphatidic Acid CAS: 325465-93-8
MF: C21H40O7P•Na
MW: 458.50

Lysophosphatidic Acid (CAS 325465-93-8)

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Lysophosphatidic Acid is rated 5.0 out of 5 by 2.
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Nombres Alternativos: Lysophosphatidic Acid also known as 1-oleoyl-sn-glycero-3-phosphate sodium salt; Oleoyl-L-α-lysophosphatidic acid sodium salt; LPA sodium salt; 3-SN-LYSOPHOSPHATIDIC ACID; 1-OLEOYL-SN-GLYCERO-3-LYSOPHOSPHATIDIC ACID SODIUM SALT; 1-OLEOYL LYSOPHOSPHATIDIC ACID SODIUM SALT
Solicitud: Lysophosphatidic Acid is a endogenous glycerophospholipid signaling ligand molecule and ligand activator for EDG-2, EDG-4, and EDG-7
Número de CAS: 325465-93-8
Pureza: ≥98%
Peso Molecular: 458.50
Fórmula Molecular: C21H40O7P•Na
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Lysophosphatidic acid (LPA) is an endogenous glycerophospholipid signaling molecule and ligand activator for EDG-2 and EDG-4 (LPA) receptors. Signaling associated with LPA has been reported to stimulate growth of fibroblasts, vascular smooth muscle cells, endothelial cells, and keratinocytes. Lysophosphatidic Acid has been indicated as both a proliferative and anti-apoptotic factor, signaling for Pl3K-mediated regulation of cell activity. Lysophosphatidic Acid has also been described to potentiate acetylchloine receptor currents by G-protein-mediated activation of Ca2+-dependent/independent protein kinase C. Lysophosphatidic Acid can bind to one of four G-protein linked receptors to mediate a variety of biological responses including smooth muscle contraction, cell proliferation, neutrite retraction and platelet aggregation.


References

1. Moolenaar, W H., et al., 1995. Lysophosphatidic acid, a multifunctional phospholipid messenger. The Journal of biological chemistry. 270(22): 12949-52. PMID: 7768880

2. Levine, J S., et al., 1997. Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. The American journal of physiology. 273(4 Pt 2): F575-85. PMID: 9362335

3. Nishizaki, T., et al., 1997. Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C. Brain research. Molecular brain research. 50(1-2): 121-6. PMID: 9406926

Uso :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Packaged under inert gas, hygroscopic, protect from light, air sensitive.
Estado de Materia :
Solid
Solubilidad :
Soluble in chloroform, methanol, acetic acid (10 mg/mL), water (5 mg/mL, with sonication), and DMSO (0.5 mg/mL, warm).
ALMACENAMIENTO :
Store at -20° C
Indice de Refracción :
n20D 1.49
IC50 :
Autotaxin: IC50 = 442 nM (human); Lysophosphatidic acid receptor Edg-4: EC5050 = 6.8 nM (human); Lysophosphatidic acid receptor 5: EC5050 = 12 nM (human)
Valores de pK :
pKa: 1.82
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
Número MDL :
MFCD00133427
SMILES :
CCCCCCCC/C=C\\CCCCCCCC(=O)OCC(COP(=O)(O)[O-])O.[Na+]

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Ver como otros han utilizado Lysophosphatidic Acid (CAS 325465-93-8). Haga click en la entrada de PubMed .

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PMID: # 33558623  Malek, N.|Michrowska, A.|Mazurkiewicz, E.|Mrówczyńska, E.|Mackiewicz, P.|Mazur, AJ.| et al. 2021. Sci Rep. 11: 3329.

PMID: # 33571521  Lu, J.|Hu, Z.|Deng, Y.|Wu, Q.|Wu, M.|Song, H.| et al. 2021. J Biol Chem. 100400.

PMID: # 30840161  Olianas, MC.|Dedoni, S.|Onali, P.| et al. 2019. Apoptosis.

PMID: # 30535430  2019. Int. J. Oncol. 54: 515-526.

PMID: # 31145906  Xu, L.|Su, J.|Guo, L.|Wang, S.|Deng, X.|Ma, S.| et al. 2019. Neuropharmacology. 155: 150-161.

PMID: # 31010479  Jobst-Schwan, T.|Hoogstraten, CA.|Kolvenbach, CM.|Schmidt, JM.|Kolb, A.|Eddy, K.|Schneider, R.|Ashraf, S.|Widmeier, E.|Majmundar, AJ.|Hildebrandt, F.| et al. 2019. Kidney Int. 95: 1079-1090.

PMID: # 29856906  Zhang, R.|Wang, J.| et al. 2018. Cancer Sci. 109: 2446-2457.

PMID: # 27754741  Handa, H.|Hashimoto, A.|Hashimoto, S.|Sabe, H.| et al. 2018. Small GTPases. 9: 420-426.

PMID: # 30031609  Lu, S. et al. 2018. Biochem. Biophys. Res. Commun. 503: 1322-1329.

PMID: # 30385786  Deng, Y.|Lu, J.|Li, W.|Wu, A.|Zhang, X.|Tong, W.|Ho, KK.|Qin, L.|Song, H.|Mak, KK.| et al. 2018. Nat Commun. 9: 4564.

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