D2Bwg1423e Activators
Brd3os, an opposite strand counterpart to BRD3, is implicated in diverse biological processes through its involvement in transcriptional regulation. The identified activators modulate Brd3os expression and function, impacting its role in cellular processes. Chemical activators like JQ1, PFI-3, and I-BET151 directly activate Brd3os by inhibiting BET bromodomains, enhancing transcriptional activity. SAHA, Trichostatin A, and Panobinostat activate Brd3os through HDAC inhibition, promoting chromatin accessibility and facilitating transcriptional activation.
Curcumin and Quercetin indirectly activate Brd3os by modulating NF-κB signaling, influencing Brd3os expression in a context-dependent manner. 5-Aza-2'-deoxycytidine and Decitabine act indirectly by demethylating DNA, altering the epigenetic landscape and promoting transcriptional activation. Resveratrol modulates Brd3os through SIRT1, affecting expression and function. Romidepsin and other identified activators collectively offer a spectrum of mechanisms to modulate Brd3os, showcasing its versatility in cellular processes. In conclusion, understanding Brd3os activation provides insights into the intricate regulatory networks influencing its role in transcriptional regulation. The identified activators offer a foundation for exploring the dynamic interplay of Brd3os in diverse cellular contexts and its potential implications in cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Directly activates Brd3os by inhibiting BET bromodomains, leading to enhanced transcriptional activity and up-regulation of Brd3os expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Activates Brd3os through HDAC inhibition, promoting chromatin accessibility and facilitating transcriptional activation of Brd3os. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Indirectly activates Brd3os by modulating NF-κB signaling, influencing Brd3os expression and function in a context-dependent manner. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Indirectly activates Brd3os by demethylating DNA, altering the epigenetic landscape and promoting transcriptional activation of Brd3os. | ||||||
PFI 3 | 1819363-80-8 | sc-507340 | 10 mg | $300.00 | ||
Directly activates Brd3os by inhibiting BET bromodomains, leading to enhanced transcriptional activity and up-regulation of Brd3os expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Activates Brd3os through HDAC inhibition, promoting chromatin accessibility and facilitating transcriptional activation of Brd3os. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Indirectly activates Brd3os by modulating SIRT1 activity, influencing Brd3os expression and function in a context-dependent manner. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
Directly activates Brd3os by inhibiting BET bromodomains, leading to enhanced transcriptional activity and up-regulation of Brd3os expression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Activates Brd3os through HDAC inhibition, promoting chromatin accessibility and facilitating transcriptional activation of Brd3os. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Indirectly activates Brd3os by modulating NF-κB signaling, influencing Brd3os expression and function in a context-dependent manner. | ||||||