Date published: 2025-12-19

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D2Bwg1423e Inhibitors

Brd3os, orthologous to human BRD3 opposite strand, exhibits broad expression in various tissues, including the cortex and central nervous system. Understanding potential inhibitors for Brd3os involves targeting its regulatory mechanisms, particularly focusing on the bromodomain since it is implicated in chromatin binding and transcriptional regulation. BET bromodomain inhibitors such as JQ1, I-BET151, CPI-203, (S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide, RVX-208, MS417, PFI-1, TEN-010, ABBV-744, and INCB054329 directly target Brd3os's bromodomain, disrupting its association with chromatin. These inhibitors hinder Brd3os's ability to modulate gene expression through chromatin remodeling, offering a specific approach to inhibit Brd3os function at the molecular level. In addition to BET bromodomain inhibitors, BI-2536 and RO-3306 indirectly impact Brd3os by targeting key kinases involved in cell cycle regulation. BI-2536 inhibits PLK1, while RO-3306 inhibits CDK1. These indirect inhibitors influence the cell cycle dynamics that Brd3os may modulate, potentially affecting its role in cellular events such as proliferation. Understanding the intricate interplay between Brd3os and its inhibitors provides valuable insights into the regulatory mechanisms of this gene and its potential implications in diverse cellular processes. The diverse set of inhibitors presented here, each with a unique mechanism of action, lays the foundation for further exploration into the molecular and functional aspects of Brd3os.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$226.00
$846.00
1
(0)

JQ1, a BET bromodomain inhibitor, directly targets the bromodomain of BRD3OS, disrupting its binding to chromatin. This inhibits BRD3OS's role in transcriptional regulation, as it is involved in chromatin remodeling. JQ1's action prevents BRD3OS from influencing gene expression by interfering with its interaction with chromatin structures.

I-BET 151 Hydrochloride

1300031-49-5 (non HCl Salt)sc-391115
10 mg
$450.00
2
(0)

I-BET151, another BET bromodomain inhibitor, directly interacts with BRD3OS bromodomain, inhibiting its association with chromatin. This disrupts BRD3OS's involvement in transcriptional regulation, as chromatin binding is essential for its function. I-BET151 hinders the ability of BRD3OS to modulate gene expression by preventing its binding to chromatin structures.

CPI-203

1446144-04-2sc-501599
1 mg
$170.00
(0)

CPI-203, a BET bromodomain inhibitor, directly targets the bromodomain of BRD3OS, interfering with its binding to chromatin. This disruption impacts BRD3OS's role in transcriptional regulation, hindering its ability to modulate gene expression through chromatin remodeling. CPI-203 prevents BRD3OS from exerting its regulatory influence on gene expression by blocking its interaction with chromatin structures.

(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide

202590-98-5sc-501130
2.5 mg
$330.00
(0)

(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide, a BET bromodomain inhibitor, directly interacts with the bromodomain of BRD3OS, disrupting its association with chromatin.

RVX 208

1044870-39-4sc-472700
10 mg
$340.00
(0)

RVX-208, a BET bromodomain inhibitor, directly targets the bromodomain of BRD3OS, inhibiting its binding to chromatin. This disruption impacts BRD3OS's role in transcriptional regulation, hindering its ability to modulate gene expression through chromatin remodeling. RVX-208 prevents BRD3OS from exerting its regulatory influence on gene expression by blocking its interaction with chromatin structures.

MS417

916489-36-6sc-507505
5 mg
$228.00
(0)

MS417, a BET bromodomain inhibitor, directly interacts with the bromodomain of BRD3OS, disrupting its association with chromatin. This interference affects BRD3OS's involvement in transcriptional regulation, impeding its ability to modulate gene expression through chromatin remodeling.

PFI-1

1403764-72-6sc-478504
5 mg
$96.00
(0)

PFI-1, a BET bromodomain inhibitor, directly targets the bromodomain of BRD3OS, inhibiting its binding to chromatin. This disruption impacts BRD3OS's role in transcriptional regulation, hindering its ability to modulate gene expression through chromatin remodeling. PFI-1 prevents BRD3OS from exerting its regulatory influence on gene expression by blocking its interaction with chromatin structures.

BI 2536

755038-02-9sc-364431
sc-364431A
5 mg
50 mg
$148.00
$515.00
8
(1)

BI-2536, a PLK1 inhibitor, indirectly impacts BRD3OS by inhibiting PLK1, a kinase involved in cell cycle regulation. This inhibition affects the cell cycle dynamics that BRD3OS may influence. BI-2536 indirectly hinders BRD3OS's function in cell cycle-related processes, potentially influencing its role in cellular events such as proliferation.

RO-3306

872573-93-8sc-358700
sc-358700A
sc-358700B
1 mg
5 mg
25 mg
$65.00
$160.00
$320.00
37
(1)

RO-3306, a CDK1 inhibitor, indirectly influences BRD3OS by inhibiting CDK1, a kinase involved in cell cycle progression. This indirect inhibition impacts the cell cycle dynamics that BRD3OS may modulate. RO-3306 hinders BRD3OS's function in cell cycle-related processes, potentially affecting its role in cellular events such as proliferation.