Molecular structure of MS417, CAS Number: 916489-36-6
MS417 (CAS 916489-36-6)
Alternate Names:
MS 417 MS-417 Methyl [(6s)-4-(4-Chlorophenyl)-2,3,9-Trimethyl-6h-Thieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-6-Yl]acetate GTPL7512 methyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate
CAS Number:
916489-36-6
Molecular Weight:
414.90
Molecular Formula:
C20H19ClN4O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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MS417 (CAS 916489-36-6) References
- Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. | Zhang, G., et al. 2012. J Biol Chem. 287: 28840-51. PMID: 22645123
- BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. | Boehm, D., et al. 2013. Cell Cycle. 12: 452-62. PMID: 23255218
- Role of transcription factor acetylation in diabetic kidney disease. | Liu, R., et al. 2014. Diabetes. 63: 2440-53. PMID: 24608443
- BRD4 inhibitor inhibits colorectal cancer growth and metastasis. | Hu, Y., et al. 2015. Int J Mol Sci. 16: 1928-48. PMID: 25603177
- Phospho-BRD4: transcription plasticity and drug targeting. | Chiang, CM. 2016. Drug Discov Today Technol. 19: 17-22. PMID: 27769352
- Development of New Positron Emission Tomography Radiotracer for BET Imaging. | Wang, C., et al. 2017. ACS Chem Neurosci. 8: 17-21. PMID: 27806195
- Targeting bromodomain and extraterminal proteins in breast cancer. | Sahni, JM. and Keri, RA. 2018. Pharmacol Res. 129: 156-176. PMID: 29154989
- SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease. | Zhong, Y., et al. 2018. Front Endocrinol (Lausanne). 9: 624. PMID: 30386303
- The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy. | Li, Z., et al. 2021. Acta Pharm Sin B. 11: 1286-1299. PMID: 34094834
- Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling. | Sun, J., et al. 2023. Br J Pharmacol. 180: 3194-3214. PMID: 37485568
Inhibitor of:
4933408B17Rik, BC032203, BCNP1, Bet1L, BRD1, BRD7, BRD8, BRMS1, BSX, D2Bwg1423e, FEZ1, MAGE-B4, RNF40, and T-bet.Activator of:
BRD4, and BRDT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MS417, 5 mg | sc-507505 | 5 mg | $228.00 |