Molecular structure of PFI 3, CAS Number: 1819363-80-8
PFI 3 (CAS 1819363-80-8)
Alternate Names:
(E)-1-(2-hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one
CAS Number:
1819363-80-8
Molecular Weight:
321.37
Molecular Formula:
C19H19N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PFI 3 (CAS 1819363-80-8) References
- The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies. | Vangamudi, B., et al. 2015. Cancer Res. 75: 3865-3878. PMID: 26139243
- The Bromodomain Inhibitor PFI-3 Sensitizes Cancer Cells to DNA Damage by Targeting SWI/SNF. | Lee, D., et al. 2021. Mol Cancer Res. 19: 900-912. PMID: 33208498
- Targeting the Bromodomain of BRG-1/BRM Subunit of the SWI/SNF Complex Increases the Anticancer Activity of Temozolomide in Glioblastoma. | Yang, C., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34577604
- Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells. | He, Y., et al. 2022. Bioorg Med Chem. 53: 116533. PMID: 34863065
- Targetable Brg1-CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking. | Li, N., et al. 2023. EMBO Mol Med. 15: e16592. PMID: 36722664
- Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis. | Jolly, AJ., et al. 2023. JCI Insight. 8: PMID: 36976650
- PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery. | Li, J., et al. 2023. PeerJ. 11: e15407. PMID: 37250720
- Unlocking cellular plasticity: Enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation. | Yang, J., et al. 2023. bioRxiv.. PMID: 37873209
- The chromatin remodeling protein BRG1 contributes to liver ischemia-reperfusion injury by regulating NOXA expression. | Li, N., et al. 2023. Life Sci. 334: 122235. PMID: 37926300
- Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy. | Wu, X., et al. 2024. Life Sci. 344: 122578. PMID: 38537899
Inhibitor of:
ARID2, BAF155, BAF170, BAF53B, BPTF, Brg-1, CBX7, DOC2B, DPF3, EPC1, FAM136A, FEZ1, MOZ, MPc2, MSL-1, PATZ1, SETD6, Six1, SMARCD3, Snf2, Sp8, Swi3, WSTF (BAZ1B), ZNF38, ZNF648, and ZSCAN4D.Activator of:
ACTR6, AF-10, BAF, D2Bwg1423e, D530049N12Rik, EG278167, ELL, Peregrin, PIAS 3, PRX V, SYT, and WDR82.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PFI 3, 10 mg | sc-507340 | 10 mg | $300.00 |