CYP4V2 Activators
CYP4V2 activators encompass a diverse group of chemicals that can modulate cytochrome P450 enzyme activity. These chemicals are known to interact with various nuclear receptors, such as PXR, CAR, and PPARs, which are transcription factors that regulate the expression of genes, including those encoding cytochrome P450 enzymes. Activators like rifampicin, phenobarbital, and dexamethasone can initiate signaling cascades that culminate in the transcriptional upregulation of cytochrome P450 enzymes. The induction of these enzymes is critical as they are involved in the metabolism of endogenous and exogenous compounds, suggesting that CYP4V2 activity could be modulated in a similar manner.
Furthermore, compounds like omeprazole and pioglitazone, through their ability to activate nuclear receptors such as CAR and PPAR-gamma, respectively, provide insight into the regulatory mechanisms controlling the expression of CYP enzymes. The interplay between these activators and the nuclear receptors can influence not only the metabolic pathways in which CYP enzymes are involved but also the homeostasis of lipid synthesis and metabolism. Similarly, compounds like sulforaphane and clofibrate, which can activate transcription factors involved in the oxidative stress response and fatty acid metabolism, provide a broader context in which the regulation of CYP4V2 can be understood.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin can induce CYP450 enzymes by activating nuclear receptors such as PXR, which may lead to increased transcription of various CYP enzymes, including potentially CYP4V2. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is known to induce certain CYP enzymes through glucocorticoid receptor-mediated mechanisms which could include CYP4V2. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole can lead to the induction of some CYP450 enzymes through the activation of constitutive androstane receptor (CAR). | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole inhibits CYP3A4, potentially causing a compensatory increase in the expression of other CYP enzymes such as CYP4V2 through feedback mechanisms. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone can activate PPAR-gamma, which may affect the transcription of various genes, including those involved in lipid metabolism and possibly CYP4V2. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine, through its calcium channel blocker activity, may affect intracellular signaling pathways that indirectly induce CYP450 enzymes. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $60.00 | 17 | |
Mifepristone acts on the glucocorticoid receptor, which might influence the expression of CYP enzymes through cross-talk with liver X receptors or PXR. | ||||||
Hyperforin | 11079-53-1 | sc-507549 | 250 µg | $420.00 | ||
Hyperforin is known to activate pregnane X receptor (PXR), which can lead to the upregulation of various CYP enzymes. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $32.00 $70.00 | 5 | |
Carbamazepine can induce the expression of CYP450 enzymes through activation of nuclear receptors like PXR and CAR. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, which can influence the expression of detoxifying enzymes, possibly including CYP4V2, as a part of the antioxidant response pathway. | ||||||