CYP4V2 Antibody (M29-P3B10): sc-101386

CYP4V2 Antibody (M29-P3B10) is a mouse monoclonal IgG1 kappa light chain antibody that detects CYP4V2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CYP4V2 antibody (M29-P3B10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CYP4V2, also known as Cytochrome P450 4V2, consists of 525 amino acids and is a member of the cytochrome P450 family, which is crucial for the metabolism of various substrates, including fatty acids and steroids. CYP4V2 is primarily localized to the endoplasmic reticulum membrane and is expressed in a wide range of human tissues, highlighting a potential role in diverse physiological processes. Defects in CYP4V2 have been associated with Bietti crystalline corneoretinal dystrophy (BCD), an autosomal recessive condition characterized by glistening intraretinal crystals, retinal degeneration, and progressive vision loss. Two isoforms of CYP4V2, resulting from alternative splicing, further emphasize the complexity of function and regulation within the body.

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CYP4V2 Antibody (M29-P3B10) References:

1. Genetic linkage of Bietti crystallin corneoretinal dystrophy to chromosome 4q35.  |  Jiao, X., et al. 2000. Am J Hum Genet. 67: 1309-13. PMID: 11001583
2. Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2.  |  Li, A., et al. 2004. Am J Hum Genet. 74: 817-26. PMID: 15042513
3. Novel mutations in the CYP4V2 gene associated with Bietti crystalline corneoretinal dystrophy.  |  Shan, M., et al. 2005. Mol Vis. 11: 738-43. PMID: 16179904
4. Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations.  |  Lee, KY., et al. 2005. Invest Ophthalmol Vis Sci. 46: 3812-6. PMID: 16186368
5. Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells.  |  Thomas, RD., et al. 2006. Chem Biol Interact. 160: 204-16. PMID: 16527260
6. Genotype phenotype analysis of Bietti's crystalline dystrophy in patients with CYP4V2 mutations.  |  Lai, TY., et al. 2007. Invest Ophthalmol Vis Sci. 48: 5212-20. PMID: 17962476
7. Novel CYP4V2 gene mutation in a Mexican patient with Bietti's crystalline corneoretinal dystrophy.  |  Zenteno, JC., et al. 2008. Curr Eye Res. 33: 313-8. PMID: 18398705
8. Effects of co-exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and perfluorooctane sulfonate or perfluorooctanoic acid on expression of cytochrome P450 isoforms in chicken (Gallus gallus) embryo hepatocyte cultures.  |  Watanabe, MX., et al. 2009. Comp Biochem Physiol C Toxicol Pharmacol. 149: 605-12. PMID: 19167519

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CYP4V2 Antibody (M29-P3B10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CYP4V2 Antibody (M29-P3B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CYP4V2 Antibody (M29-P3B10) Specifications

Alternate Product Name: CYP4V2

Product Clone Name: M29-P3B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 495-504

Epitope Target: CYP4V2

Epitope Species: human

Product Reactivity/Detection: CYP4V2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CYP4V2 Antibody (M29-P3B10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin