CYP4V2 Antibody (M29-P3B10): sc-101386
- CYP4V2 Antibody (M29-P3B10) is a mouse monoclonal IgG1 κ CYP4V2 antibody provided at 200 µg/ml
- raised against a synthetic peptide corresponding to amino acids 495-504 of CYP4V2 of human origin
- CYP4V2 Antibody (M29-P3B10) is recommended for detection of CYP4V2 of human origin by WB, IP and ELISA
- Anti-CYP4V2 Antibody (M29-P3B10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CYP4V2 Antibody (M29-P3B10) for WB applications. These reagents are now offered in bundles with CYP4V2 Antibody (M29-P3B10) (see ordering information below).
CYP4V2 Antibody (M29-P3B10) is a mouse monoclonal IgG1 kappa light chain antibody that detects CYP4V2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CYP4V2 antibody (M29-P3B10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CYP4V2, also known as Cytochrome P450 4V2, consists of 525 amino acids and is a member of the cytochrome P450 family, which is crucial for the metabolism of various substrates, including fatty acids and steroids. CYP4V2 is primarily localized to the endoplasmic reticulum membrane and is expressed in a wide range of human tissues, highlighting a potential role in diverse physiological processes. Defects in CYP4V2 have been associated with Bietti crystalline corneoretinal dystrophy (BCD), an autosomal recessive condition characterized by glistening intraretinal crystals, retinal degeneration, and progressive vision loss. Two isoforms of CYP4V2, resulting from alternative splicing, further emphasize the complexity of function and regulation within the body.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CYP4V2 Antibody (M29-P3B10) References:
- Genetic linkage of Bietti crystallin corneoretinal dystrophy to chromosome 4q35. | Jiao, X., et al. 2000. Am J Hum Genet. 67: 1309-13. PMID: 11001583
- Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2. | Li, A., et al. 2004. Am J Hum Genet. 74: 817-26. PMID: 15042513
- Novel mutations in the CYP4V2 gene associated with Bietti crystalline corneoretinal dystrophy. | Shan, M., et al. 2005. Mol Vis. 11: 738-43. PMID: 16179904
- Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations. | Lee, KY., et al. 2005. Invest Ophthalmol Vis Sci. 46: 3812-6. PMID: 16186368
- Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells. | Thomas, RD., et al. 2006. Chem Biol Interact. 160: 204-16. PMID: 16527260
- Genotype phenotype analysis of Bietti's crystalline dystrophy in patients with CYP4V2 mutations. | Lai, TY., et al. 2007. Invest Ophthalmol Vis Sci. 48: 5212-20. PMID: 17962476
- Novel CYP4V2 gene mutation in a Mexican patient with Bietti's crystalline corneoretinal dystrophy. | Zenteno, JC., et al. 2008. Curr Eye Res. 33: 313-8. PMID: 18398705
- Effects of co-exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and perfluorooctane sulfonate or perfluorooctanoic acid on expression of cytochrome P450 isoforms in chicken (Gallus gallus) embryo hepatocyte cultures. | Watanabe, MX., et al. 2009. Comp Biochem Physiol C Toxicol Pharmacol. 149: 605-12. PMID: 19167519
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP4V2 Antibody (M29-P3B10) | sc-101386 | 200 µg/ml | $322.00 | |||
CYP4V2 Antibody (M29-P3B10): m-IgG Fc BP-HRP Bundle | sc-528718 | 200 µg Ab; 10 µg BP | $361.00 | |||
CYP4V2 Antibody (M29-P3B10): m-IgGκ BP-HRP Bundle | sc-521189 | 200 µg Ab, 40 µg BP | $361.00 | |||
CYP4V2 Antibody (M29-P3B10): m-IgG1 BP-HRP Bundle | sc-543088 | 200 µg Ab; 20 µg BP | $361.00 | |||
CYP4V2 Antibody (M29-P3B10) AC | sc-101386 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CYP4V2 Antibody (M29-P3B10) HRP | sc-101386 HRP | 200 µg/ml | $322.00 | |||
CYP4V2 Antibody (M29-P3B10) FITC | sc-101386 FITC | 200 µg/ml | $336.00 | |||
CYP4V2 Antibody (M29-P3B10) PE | sc-101386 PE | 200 µg/ml | $349.00 | |||
CYP4V2 Antibody (M29-P3B10) Alexa Fluor® 488 | sc-101386 AF488 | 200 µg/ml | $364.00 | |||
CYP4V2 Antibody (M29-P3B10) Alexa Fluor® 546 | sc-101386 AF546 | 200 µg/ml | $364.00 | |||
CYP4V2 Antibody (M29-P3B10) Alexa Fluor® 594 | sc-101386 AF594 | 200 µg/ml | $364.00 | |||
CYP4V2 Antibody (M29-P3B10) Alexa Fluor® 647 | sc-101386 AF647 | 200 µg/ml | $364.00 | |||
CYP4V2 Antibody (M29-P3B10) Alexa Fluor® 680 | sc-101386 AF680 | 200 µg/ml | $364.00 | |||
CYP4V2 Antibody (M29-P3B10) Alexa Fluor® 790 | sc-101386 AF790 | 200 µg/ml | $364.00 |