CYP4V2 Inhibitors
CYP4V2 Inhibitors are compounds primarily recognized for their ability to modulate the metabolic activity of the CYP4V2 enzyme. Many of these chemicals, such as ketoconazole and fluconazole, are known for their antifungal properties. Their mechanism of action involves binding to the active site of P450 enzymes, competing for substrate binding, or inducing conformational changes that render the enzyme inactive. These alterations can lead to reduced metabolism of the substrates specific to CYP4V2, affecting fatty acid metabolic processes.
Several of the inhibitors, including cimetidine and chloramphenicol, demonstrate a broad spectrum of inhibitory effects on multiple P450 enzymes, not just CYP4V2. Their interaction with these enzymes often involves the competition for the heme iron binding site or structural modifications that prevent substrate access.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
An antifungal agent that inhibits several cytochrome P450 isoforms. Its presence can reduce the metabolic activity of CYP4V2 by binding to the heme iron, inhibiting substrate access. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Antifungal primarily targeting CYP2C9 and CYP3A4 but can indirectly influence CYP4V2 activity by competing for enzyme binding sites. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
H2 receptor antagonist that inhibits several P450 enzymes, potentially decreasing CYP4V2 activity by competing for the heme binding site. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
An antibiotic known to inhibit P450 enzymes, possibly reducing CYP4V2 activity by causing a structural change that prevents substrate binding. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
An antifungal agent inhibiting various P450 isoforms. It can influence CYP4V2 activity by altering the heme environment or blocking substrate access. | ||||||
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
An antifungal agent inhibiting P450 enzymes. It can modulate CYP4V2 activity by binding to the enzyme's active site, preventing substrate access. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Macrolide antibiotic that inhibits several P450 isoforms. Its binding to CYP4V2 can prevent substrate metabolism by steric hindrance. | ||||||
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $26.00 $101.00 $146.00 | ||
Antitubercular agent that inhibits P450 enzymes, possibly impacting CYP4V2 by binding to its active site, blocking substrate metabolism. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Calcium channel blocker that inhibits P450 enzymes. Its interaction with CYP4V2 can alter the enzyme's conformation, impacting substrate metabolism. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Antiarrhythmic agent that inhibits P450 enzymes. Its binding can induce a structural change in CYP4V2, disrupting substrate metabolism. | ||||||