Hyperforin (CAS 11079-53-1)
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Hyperforin inhibits the uptake of the monoamine neurotransmitters serotonin, dopamine, noradrenaline, and GABA. The specific mechanism of serotonin uptake inhibition is correlated with Hyperforin-induced elevation of intracellular Na+ levels. AMPA induced currents were shown to be competitively and incompletely inhibited by Hyperforin, while NMDA receptor-activated ionic conductance was completely and uncompetitively inhibited. Hyperforin is described to present neuroprotective effects, demonstrating the induction of amyloid-beta aggregate disassembly, improvement of spatial memory, and decrease of astrogliosis and microglia activation. The action of inducible nitric oxide synthase (iNOS) was modulated by Hyperforin, demonstrating reduced NO production through suppression of iNOS on the mRNA and protein levels, further correlating to the neuroprotection generated by this compound. Hyperforin demonstrates selective activation of the transient receptor potential channel TRPC6. Activation of the pregnane X receptor by Hyperforin produces induction of cytochrome p450 3A4 monooxygenase expression, promoting oxidation metabolism activity of this enzyme.
Hyperforin (CAS 11079-53-1) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hyperforin, 250 µg | sc-507549 | 250 µg | $420.00 |