Nicardipine hydrochloride CAS: 54527-84-3
MF: C26H29N3O6•HCl
MW: 515.98
A potent calcium channel protein inhibitor.

Nicardipine hydrochloride (CAS 54527-84-3)

Nicardipine hydrochloride | CAS 54527-84-3 is rated 5.0 out of 5 by 2.
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Alternate Names: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride; YC-93
Application: Nicardipine hydrochloride is a potent calcium channel protein inhibitor
CAS Number: 54527-84-3
Purity: ≥98%
Molecular Weight: 515.98
Molecular Formula: C26H29N3O6•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Nicardipine hydrochloride is the hydrochloride salt preparation of Nicardipine and a potent L-type calcium channel protein inhibitor. Nicardipine is described to alter cytochrome P-450 3A expression through induction of CYP3A. Nicardipine blockade of Ca2+ channels has been correlated to antihypertensive effects.


References

1. Triggle, D.J. and Rampe, D. 1989. Trends Pharmacol. Sci. 10: 507-511. PMID: 2694544
2. Japelj, I., et al. 1999. Eur. J. Pharmacol. 369: 43-47. PMID: 10204680
3. Matsuda, T. and Kurata, Y. 1999. Gen. Pharmacol. 33: 115-125. PMID: 10461849
4. Zangar, R.C., et al. 1999. J. Pharmacol. Exp. Ther. 290: 1436-1441. PMID: 10454523
5. Thellung, S., et al. 2000. Neurobiol. Dis. 7: 299-309. PMID: 10964602

Physical State :
Solid
Solubility :
Soluble in DMSO (1 mg/ml), water (slightly), methanol (50 mg/ml), chloroform (slightly), and 100% ethanol (slightly).
Storage :
Store at 4° C
Melting Point :
168-170° C
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Sus scrofa: IC50 = 0.3 nM; Voltage-gated L-type calcium channel: IC50 = 2.66 nM (rat); Mdr-1: IC50 = 0.95 µM (human); Plasmodium falciparum: IC50 = 1.00 µM; Adrenergic receptor alpha-2: IC50 = 1.40 µM (rat)
Ki Data :
Voltage-gated L-type calcium channel: Ki= 0.84 nM (rat); CYP2C9: Ki= 0.28 µM (human); Adenosine A3-R: Ki= 3.25 µM (human); Equilibrative nucleoside transporter 1: Ki= 5.36 µM (rat); Adenosine A1 receptor: Ki= 19.6 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
US7972100
PubChem CID :
41114
Merck Index :
14: 6495
MDL Number :
MFCD00057327
EC Number :
259-198-4
SMILES :
Cl.COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C1

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Certificate of Analysis

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Nicardipine hydrochloride (CAS 54527-84-3)  Product Citations

See how others have used Nicardipine hydrochloride (CAS 54527-84-3). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24793242  Joseph, EK. et al. 2014. J Pain. 15: 771-7.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from I have used it for metID study and it work I have used it for metID study and it work very Fine!!!!
Date published: 2015-10-30
Rated 5 out of 5 by from Huang Huang, BR. et al. (PubMed 24621589) presented the calcium channel blocker Nicardipine as a potential neuroprotector due to its anti-neuroinflammatory effects on microglial cells. -SCBT Publication Review
Date published: 2015-05-02
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