Molecular structure of Mifepristone, CAS Number: 84371-65-3
Mifepristone (CAS 84371-65-3)
See product citations (17)
Alternate Names:
11β-(4-Dimethylamino)phenyl-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; RU-486
Application:
Mifepristone is a progesterone and glucocorticoid antagonist, suppresses VEGF production
CAS Number:
84371-65-3
Purity:
≥98%
Molecular Weight:
429.59
Molecular Formula:
C29H35NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Mifepristone is a progesterone (PR) and glucocorticoid receptor (GR) antagonist which has demonstrated the ability to suppress activation of NFkappaB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. It is also an inhibitor of the progesterone receptor. Mifepristone has been found to decrease basal bcl-2 messenger RNA levels in CA1 neural regions and the dentate gyrus. Experiments have shown that mifepristone potentially exhibits an inhibitory effect on embryo implantation via regulation of FAS and FAS-L apoptosis gene expression. Additionally, mifepristone displays anti-angiogenic characteristics via suppression of vascular endothelial growth factor (VEGF) production. Mifepristone may also prevent intracellular peroxide accumulation and cell death induced by hydrogen peroxide, glutamate, beta-amyloid protein, or neurotoxins that have been associated with certain neurodegenerative disorders.
Mifepristone (CAS 84371-65-3) References
- Differential expression of members of the tumor necrosis factor alpha-related apoptosis-inducing ligand pathway in prostate cancer cells. | Sridhar, S., et al. 2001. Cancer Res. 61: 7179-83. PMID: 11585752
- Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium. | Gao, F., et al. 2001. Acta Pharmacol Sin. 22: 524-9. PMID: 11747759
- Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat. | McCullers, DL., et al. 2002. Neuroscience. 109: 219-30. PMID: 11801359
- Regulation and modulation of abnormal immune responses in endometriosis. | Sidell, N., et al. 2002. Ann N Y Acad Sci. 955: 159-73; discussion 199-200, 396-406. PMID: 11949945
- Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells. | Bernal-Sore, I., et al. 2018. Mol Cell Endocrinol. 461: 277-283. PMID: 28943275
- Mifepristone Treatment in Pregnant Murine Model Induced Mammary Gland Dysplasia and Postpartum Hypogalactia. | Zhu, H., et al. 2020. Front Cell Dev Biol. 8: 102. PMID: 32154252
- Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β. | Li, Y., et al. 2021. Immunopharmacol Immunotoxicol. 43: 85-93. PMID: 33406939
- Mifepristone enhances the neural efficiency of human visuospatial memory encoding and recall. | Yalin, N., et al. 2021. Psychoneuroendocrinology. 125: 105116. PMID: 33418240
- Mifepristone regulates macrophage-mediated natural killer cells function in decidua. | Cao, L., et al. 2021. Reprod Biol. 21: 100541. PMID: 34365238
- Mifepristone Increases Life Span of Virgin Female Drosophila on Regular and High-fat Diet Without Reducing Food Intake. | Landis, GN., et al. 2021. Front Genet. 12: 751647. PMID: 34659367
- Mifepristone's effects on depression- and anxiety-like behavior in rodents. | Nayana, J., et al. 2022. Steroids. 184: 109058. PMID: 35679911
- Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity. | Landis, GN., et al. 2022. Front Aging. 3: 924957. PMID: 35935727
- Clinical Update on Uses for Mifepristone in Obstetrics and Gynecology. | Hagey, JM., et al. 2022. Obstet Gynecol Surv. 77: 611-623. PMID: 36242531
- Protection against oxidative stress-induced neuronal cell death--a novel role for RU486. | Behl, C., et al. 1997. Eur J Neurosci. 9: 912-20. PMID: 9182944
- Vascular endothelial growth factor in primate endometrium is regulated by oestrogen-receptor and progesterone-receptor ligands in vivo. | Greb, RR., et al. 1997. Hum Reprod. 12: 1280-92. PMID: 9222018
Inhibitor of:
α-centractin, 17-β Estradiol 6, 17β-HSD11, 17β-HSD14, 17β-HSD2, 17β-HSD6, 17β-HSD8, AKR1D1, Angiogenesis, Annexin II, ARG-Vasopressin, C10orf12, C1orf74, CD163L1, Chemokine Receptor D6, Choriogonadotropin, Choriogonadotropin β, Choriogonadotropin Holo c2, Choriogonadotropin Holo c3, CLEC-2F, CLEC-2G, CMV gB, Cortisol, CRHSP-24, CSH1, CYP11B, CYP3A, DAX-1, Desmin, DEXI, EG384585, EG626305, ERRβ, Estradiol, FAM196B, FEV, FKBP52, FMNL3, FNDC4, GCDFP-15, GLCCI1, GnRH-associated peptide, Gonadotropin β, GR, GREB1, IFN-α12, karyopherin α, karyopherin α1, karyopherin β3, katacalcin, KBTBD10, LCOR, LOC642366, LOC643909, LRRC59, MC2-R, mPR, mPRα, mPRδ, mPRε, mPRγ, MRAP, Neuromedin N, NK-3R, NOBOX, NRIP, Olfr250, Olfr821, Oviductin, PBR, Per3, PGRMC1, PIBF, Placental lactogen II, Plfr, PLP-J, PLP-K, PR, Progesterone, Progesterone Receptor, progonadoliberin I, PSE1, Purγ, SC, SerpinA6, SHBG, SMR3A, SPANX-A, SRC-1, TAF1L, TBX19, TMEM16B, TRβ, TRH-R2, UGT1A2, V1rc3132, V1RG3, VDAC2, Vmn1r135, Vmn1r155, Vmn2r2, Vmn2r24, Vmn2r32, Vmn2r48, Vmn2r59, Vmn2r77, Vmn2r81, XAF1, and ZP2.Activator of:
β-SNAP, 11β-HSD2, A1-b, Arylsulfatase H, ASTE1, Bicoid, BTF3L4, C1orf49, C1orf65, C1orf93, C1orf94, C3orf23, CACHD1, CCDC18, CCDC81, CDV envelope antigen, Choriogonadotropin, Complexin-1, Cre Recombinase, CYP17A1, Cyp3a18, CYP4V2, DDX32, Dengue Virus 3, DLEU7, DSC1B, DsRed, Dynein IC1, cytosolic, EBFP, EHD1, FAM11B, FAM178A, FAM183B, FBXO27, Fibrocystin L, FKBP51, FKBP52, GAL4 (DBD), GATAD1, GBX2, GGNBP1, GILZ, GMEB-1, GSC, HOOK3, HRP-3, IQCF4, Iws1, Katanin p60 AL2, KBTBD12, KIAA1522, KLHL21, Lacrein, LOC100039282, LOC100039560, LOC100039674, LOC100039794, LOC100040214, LOC100040491, LOC100040781, LOC100040870, LOC100040962, LOC100041004, LOC100041139, LOC100041296, MACS1, MFSD1, MIF4GD, MUP6, NELF-D, Neuritin, NOTO, NPAS3, OR2G2, OR6F1, PADI6, PGRMC2, PRAMEF19, PRPF38B, PRR23B, PSG, RBM7, RGPD, RPAP2, RUSC1, SCCPDH, SEC22A, SID-1, Slxl1, TBL1X, TBL1XR1, TPRG1, TTMP_BC030499, Vaccinia Virus, VCX-A, VLP, XTP13, YFP, ZFP64, ZNF442, ZNF499, ZNF651, and ZNF697.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mifepristone, 100 mg | sc-203134 | 100 mg | $60.00 |