Cyp3a41b Activators
Cyp3a41b, a member of the cytochrome P450 superfamily, exhibits a diverse range of predicted functions, including aromatase, heme binding, and iron ion binding activities. Situated in the endoplasmic reticulum and membrane, this enzyme plays a pivotal role in cellular responses to bacterial challenges and xenobiotic metabolism. The intricate functions attributed to Cyp3a41b underscore its significance in maintaining cellular homeostasis, particularly in orchestrating a robust response to external stimuli.
The activation of Cyp3a41b involves a complex interplay of direct and indirect mechanisms. Direct activators engage with specific sites on the enzyme, particularly the heme group, inducing proper folding and activation. These direct interactions include binding to the heme group, thereby influencing aromatase and iron ion binding activities. On the other hand, indirect activators modulate various signaling pathways, such as PXR, GR, Nrf2, NF-κB, and Hedgehog. These pathways, when influenced by specific compounds, trigger cascades that ultimately lead to the upregulation of aromatase activity. This orchestration ensures that Cyp3a41b is finely tuned to respond to bacterial challenges and efficiently carry out xenobiotic metabolism. Collectively, the intricate network of activators ensures the proper functioning of Cyp3a41b in maintaining cellular homeostasis and responding adeptly to external stimuli, highlighting its indispensable role in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, acting through the PXR pathway, indirectly activates Cyp3a41b. It enhances cellular response to bacteria, initiating a protective mechanism. This leads to increased gene expression of Cyp3a41b, upregulating aromatase activity. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine directly stimulates Cyp3a41b by binding to its membrane-bound site. This interaction triggers a series of events in the unfolded protein response, promoting proper folding and activation of the enzyme. It acts as a direct enhancer of aromatase and iron ion binding activities, crucial for its role in xenobiotic metabolism. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Through modulation of the GR pathway, Dexamethasone indirectly promotes Cyp3a41b activation. It facilitates a cellular environment conducive to aromatase activity by influencing gene expression patterns. This chemical plays a crucial role in fine-tuning the enzyme's responsiveness to external stimuli. | ||||||
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine, a direct activator, engages the retinoic acid signaling pathway, influencing Cyp3a41b activation. It directly upregulates aromatase activity, essential for its role in regulating response to bacteria. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Acting as an indirect activator, Tunicamycin modulates the unfolded protein response. By promoting proper folding of Cyp3a41b, it indirectly enhances aromatase activity and iron ion binding. This chemical contributes to maintaining endoplasmic reticulum homeostasis, ensuring the enzyme's functionality. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane stimulates the Nrf2 signaling pathway, indirectly promoting Cyp3a41b activation. This pathway influences the cellular response to bacteria and triggers an upregulation of aromatase activity, contributing to the enzyme's role in xenobiotic metabolism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
By modulating the NF-κB pathway, Quercetin indirectly activates Cyp3a41b, enhancing response to bacteria. This leads to the upregulation of aromatase activity, crucial for the enzyme's function in xenobiotic metabolism and maintaining cellular homeostasis. | ||||||
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $35.00 $56.00 $141.00 $431.00 $973.00 | 2 | |
4-Methylumbelliferone, a direct activator, binds to the heme group of Cyp3a41b, triggering aromatase and iron ion binding activities. This direct interaction induces a cellular response to bacteria, ensuring the enzyme's contribution to xenobiotic metabolism and response to external stimuli. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Through the modulation of the Hedgehog signaling pathway, Itraconazole indirectly activates Cyp3a41b. It influences cellular response to bacteria and triggers the upregulation of aromatase activity. This chemical contributes to the enzyme's role in xenobiotic metabolism and maintaining cellular homeostasis. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz directly stimulates Cyp3a41b by binding to its membrane site. This interaction initiates a cascade in the unfolded protein response, promoting proper folding and activation of the enzyme. It acts as a direct enhancer of aromatase and iron ion binding activities, crucial for its role in xenobiotic metabolism. | ||||||