4-Methylumbelliferone (CAS 90-33-5)
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4-Methylumbelliferone, also known as hymecromone, is a compound that has attention in various research disciplines, primarily due to its role as a fluorescent probe in the study of enzyme activity. It is particularly valuable in enzymology, where it is used to monitor the activity of hyaluronidases, enzymes that degrade hyaluronic acid, which is a vital component of the extracellular matrix. As a result, it aids in the understanding of cellular processes and matrix biology. Additionally, in environmental sciences, this compound is applied in the quantification of glycosaminoglycan presence in various biological samples, serving as a tool for monitoring the dynamics of these polysaccharides in ecosystems. Its fluorescence properties are also utilized in the development of sensitive and selective biosensors, contributing to advancements in bioanalytical methods.
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4-Methylumbelliferone (CAS 90-33-5) References
- Antioxidant Activities of 4-Methylumbelliferone Derivatives. | Al-Majedy, YK., et al. 2016. PLoS One. 11: e0156625. PMID: 27243231
- 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. | Grandoch, M., et al. 2019. Nat Metab. 1: 546-559. PMID: 31602424
- Suppression of murine osteoarthritis by 4-methylumbelliferone. | Tsuchiya, S., et al. 2020. J Orthop Res. 38: 1122-1131. PMID: 31774188
- Characteristics of Hyaluronan Synthesis Inhibition by 4-Methylumbelliferone in Orbital Fibroblasts. | Galgoczi, E., et al. 2020. Invest Ophthalmol Vis Sci. 61: 27. PMID: 32084270
- 4-Methylumbelliferone fused oxazole thioether derivatives: synthesis, characterization and antifungal activities. | Xu, HL., et al. 2022. Nat Prod Res. 36: 707-713. PMID: 32757631
- 4-Methylumbelliferone promotes the migration and odontogenetic differentiation of human dental pulp stem cells exposed to lipopolysaccharide in vitro. | Chen, W., et al. 2021. Cell Biol Int. 45: 1415-1422. PMID: 33675275
- 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication. | Saga, R., et al. 2021. Sci Rep. 11: 8258. PMID: 33859324
- 4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy for chronic prostatitis. | Chen, J., et al. 2021. Prostate. 81: 1078-1090. PMID: 34320251
- 4-Methylumbelliferone suppresses catabolic activation in anterior cruciate ligament-derived cells via a mechanism independent of hyaluronan inhibition. | Idota, M., et al. 2021. J Orthop Surg Res. 16: 507. PMID: 34404442
- 4-Methylumbelliferone induces antitumor effects independently of hyaluronan synthesis inhibition in human acute leukemia cell lines. | Díaz, M., et al. 2021. Life Sci. 287: 120065. PMID: 34678263
- Glycosylated 4-methylumbelliferone as a targeted therapy for hepatocellular carcinoma. | Weiz, G., et al. 2022. Liver Int. 42: 444-457. PMID: 34800352
- Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice. | Dubisova, J., et al. 2022. Brain Res Bull. 181: 144-156. PMID: 35066096
- Dual targeting nanoparticles based on hyaluronic and folic acids as a promising delivery system of the encapsulated 4-Methylumbelliferone (4-MU) against invasiveness of lung cancer in vivo and in vitro. | Essa, ML., et al. 2022. Int J Biol Macromol. 206: 467-480. PMID: 35202638
- 4-Methylumbelliferone Targets Revealed by Public Data Analysis and Liver Transcriptome Sequencing. | Tsitrina, AA., et al. 2023. Int J Mol Sci. 24: PMID: 36768453
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methylumbelliferone, 25 g | sc-206910 | 25 g | $34.00 | |||
4-Methylumbelliferone, 100 g | sc-206910A | 100 g | $55.00 | |||
4-Methylumbelliferone, 250 g | sc-206910B | 250 g | $138.00 | |||
4-Methylumbelliferone, 1 kg | sc-206910C | 1 kg | $423.00 | |||
4-Methylumbelliferone, 2.5 kg | sc-206910D | 2.5 kg | $954.00 |