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Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. It is effective against several chemically induced tumor models. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. Oltipraz is an activator of Nrf2.
Bueding E, Dolan P, Leroy JP. Res Commun Chem Pathol Pharmacol. 37:293-303 (1982). Wattenberg LW, Bueding E. Carcinogenesis. 7:1379-81 (1986). Kensler T, Styczynski P, Groopman J et al. J Cell Biochem Suppl. 16I:167-72 (1992).
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