Molecular structure of Amodiaquine, CAS Number: 86-42-0
Amodiaquine (CAS 86-42-0)
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Application:
Amodiaquine is An anti-malarial and anti-inflammatory compound
CAS Number:
86-42-0
Molecular Weight:
355.86
Molecular Formula:
C20H22ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Amodiaquine is a synthetic compound with a chemical structure that includes a 4-aminoquinoline core. Amodiaquine′s aromatic structure and potential for forming stable complexes with various metals could be of interest in the field of analytical chemistry. Here, it might be explored for use in colorimetric tests, where changes in color can indicate the presence of specific metal ions or other analytes. Amodiaquine can be included in the design of organic light-emitting diodes (OLEDs) or other electronic devices that utilize organic molecules as active components. The planar structure of the quinoline moiety may facilitate charge transport, a desirable feature in such applications.
Amodiaquine (CAS 86-42-0) References
- Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria. | Humphreys, GS., et al. 2007. Antimicrob Agents Chemother. 51: 991-7. PMID: 17194834
- Artesunate-amodiaquine for the treatment of uncomplicated malaria. | Sirima, SB. and Gansané, A. 2007. Expert Opin Investig Drugs. 16: 1079-85. PMID: 17594191
- Amodiaquine pharmacogenetics. | Gil, JP. 2008. Pharmacogenomics. 9: 1385-90. PMID: 18855526
- Artesunate-amodiaquine combination therapy in the absence of malarial parasite infection induces oxidative damage in female rats. | Abolaji, AO., et al. 2014. Cell Biochem Funct. 32: 303-8. PMID: 24301325
- A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum. | Childs, GE., et al. 1989. Am J Trop Med Hyg. 40: 7-11. PMID: 2644858
- Amodiaquine-induced reproductive toxicity in adult male rats. | Niu, YR., et al. 2016. Mol Reprod Dev. 83: 174-82. PMID: 26647924
- Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds. | Bierwisch, A., et al. 2016. Toxicol Lett. 246: 49-56. PMID: 26851641
- Assessment of formulated amodiaquine microparticles in Leishmania donovani infected rats. | Nettey, H., et al. 2017. J Microencapsul. 34: 21-28. PMID: 28067090
- Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing. | Ali, AM., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 30038039
- Synthesis of novel amodiaquine analogs and evaluation of their in vitro and in vivo antimalarial activities. | Tahghighi, A., et al. 2019. J Vector Borne Dis. 56: 221-230. PMID: 32655071
- High-throughput quantitation method for amodiaquine and desethylamodiaquine in plasma using supported liquid extraction technology. | Kaewkhao, K., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1179: 122887. PMID: 34364298
- Development of single- and multiplex immunoassays for rapid detection and quantitation of amodiaquine in ACT drugs and rat serum. | Qian, J., et al. 2022. Anal Bioanal Chem. 414: 1631-1640. PMID: 34846541
- Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries. | Willems, S., et al. 2022. ChemMedChem. 17: e202200026. PMID: 35132775
Inhibitor of:
CKR-3, Cyp2c40, CYPOR, Cytokeratin 14, DDTL, EG226601, MafF, NDUFAB1, NDUFB10, NSUN7, SETD4, TGE Virus, Trimethyl Arg Asymmetric, VASA, and ZNF607.Activator of:
CES2, CYP2A6, CYP2AB1, CYP2B9, CYP2D40, Cyp3a16, Cyp3a41b, Cyp3a44, Cyp3a59, CYP4F11, EG226601, EG226604, and POLDIP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amodiaquine, 10 mg | sc-207282 | 10 mg | $342.00 |