CREST Activators
The CREST Activators are a group of chemicals that enhance the functional activity of CREST primarily through influencing the cAMP-CREB signaling pathway, a biological process directly involving CREST. These activators, which include phosphodiesterase inhibitors such as Forskolin, IBMX, Rolipram, Zaprinast, Vinpocetine, Milrinone, Anagrelide, Dipyridamole, Cilostazol, and Theophylline, increase cAMP levels. Elevated cAMP levels activate the CREB signaling pathway, in which CREST acts as a co-activator. Thus, by initiating the activation of CREB, these compounds indirectly enhance the co-activator function of CREST.
Furthermore, CREST Activators include protein kinase A inhibitors like H-89 and KT5720. Protein kinase A is responsible for phosphorylating and activating CREB. However, when protein kinase A is inhibited by these compounds, it indirectly enhances the demand for CREST's co-activator function. This is because in the absence of phosphorylated (and thus activated) CREB, more CREST is required to achieve the same level of CREB activation. Therefore, through these specific mechanisms, the compounds listed above can enhance the functional activity of CREST.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases cyclic AMP (cAMP) levels. Increased cAMP enhances the CREB signaling pathway, leading to enhanced CREST activity, as CREST is a co-activator of CREB. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterase, leading to increased cAMP levels. This enhancement of cAMP levels can activate the CREB signaling pathway, thus enhancing CREST activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a phosphodiesterase 4 inhibitor, leading to increased cAMP levels. This enhancement of cAMP levels can activate the CREB pathway, thus enhancing CREST activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is a phosphodiesterase 5 inhibitor, leading to increased cAMP levels. This enhancement of cAMP levels activates the CREB pathway, thus enhancing CREST activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a protein kinase A inhibitor. As protein kinase A is responsible for phosphorylating and activating CREB, inhibition of protein kinase A by H-89 can indirectly enhance CREST activity by increasing the demand for its co-activator function. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
KT5720 is a potent inhibitor of protein kinase A. Similar to H-89, KT5720 can indirectly enhance CREST activity by increasing the demand for its co-activator function. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a phosphodiesterase 1 inhibitor, leading to increased cAMP levels. This enhancement of cAMP levels can activate the CREB pathway, thus enhancing CREST activity. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone is a phosphodiesterase 3 inhibitor, leading to increased cAMP levels. This enhancement of cAMP levels activates the CREB pathway, thus enhancing CREST activity. | ||||||
Anagrelide hydrochloride | 58579-51-4 | sc-203513 sc-203513A | 10 mg 50 mg | $103.00 $587.00 | 1 | |
Anagrelide is a phosphodiesterase 3 inhibitor, leading to increased cAMP levels. This enhancement of cAMP levels can activate the CREB pathway, thus enhancing CREST activity. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole is a phosphodiesterase inhibitor, leading to increased cAMP levels. This enhancement of cAMP levels can activate the CREB pathway, thus enhancing CREST activity. | ||||||