CREST Inhibitors

The chemical class known as CREST Inhibitors is primarily composed of compounds that modulate chromatin remodeling and gene expression, indirectly affecting the function of CREST (SS18L1). CREST, being involved in chromatin structure and gene regulation, can be influenced by alterations in the chromatin landscape and DNA methylation patterns. The inhibitors listed target various aspects of these processes, thereby potentially modulating CREST's activity in gene expression. Compounds such as Trichostatin A, Vorinostat, RGFP966, Entinostat, Panobinostat, Romidepsin, MS-275, and SAHA are HDAC inhibitors. These inhibitors play a significant role in altering chromatin structure by affecting histone acetylation levels. By doing so, they can influence the accessibility of chromatin for transcription factors and other regulatory proteins, including CREST. This alteration in chromatin structure can lead to changes in gene expression patterns, which are areas where CREST is known to be involved.

Furthermore, DNA methyltransferase inhibitors like 5-Azacytidine and Decitabine impact DNA methylation, a critical process in epigenetic regulation of gene expression. By altering methylation patterns, these inhibitors can affect the expression of genes regulated by CREST. Valproic Acid, another HDAC inhibitor, also contributes to the modulation of chromatin structure and gene expression, further illustrating the broad spectrum of mechanisms through which the function of CREST can be influenced.