CD40L Activators
CD40L Activators encompass a diverse array of chemical compounds that indirectly bolster the activity of CD40L by modulating various intracellular signaling pathways. Resveratrol, through its action on mRNA stability, enhances CD40L activity by promoting its expression on T-cells, which is essential for T-cell-mediated immunity. Similarly, Piperlongumine augments CD40L function by increasing the expression of its receptor CD40 on antigen-presenting cells, thereby facilitating a more robust T-cell interaction. Quercetin and Curcumin both influence the NF-κB pathway, a pivotal regulator of immune response, leading to upregulated CD40L expression on activated T-cells. This modulation is crucial for the amplification of CD40L's immunostimulatory role. Sulforaphane and Epigallocatechin gallate (EGCG) also target the NF-κB pathway, potentially promoting CD40L-mediated interactions and T-cell activation. Withaferin A specifically induces CD40L expression by activating the NF-κB transcription factor, thereby enhancing CD40L's function in immune modulation.
Furthermore, Anacardic acid, through its modulation of the NF-κB signaling, is posited to upregulate CD40L expression, thus contributing to its pivotal role in initiating and sustaining immune responses. Kaempferol's influence on the same pathway can lead to enhanced CD40L activity, crucial for effective T-cell and B-cell collaboration. Fisetin, by modulating signaling pathways such as NF-κB, indirectly promotes CD40L's role in immune system activation. Genistein, as a tyrosine kinase inhibitor, could heighten CD40L function by altering T-cell activation processes, thereby facilitating increased expression and activity of CD40L on T-cells. Lastly, Apigenin's impact on NF-κB signaling correlates with an enhancement of CD40L activity, reinforcing its essential function in the activation of the immune system. Collectively, these compounds, through their targeted modulation of cellular pathways, serve to potentiate the function of CD40L without necessitating direct activation or increased gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to have immunomodulatory effects and can enhance the CD40-CD40L interaction by promoting the stabilization of CD40L mRNA, thus potentially leading to enhanced CD40L activity on the surface of T-cells which is crucial for its immunostimulatory role. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases the expression of co-stimulatory molecules, including CD40, on antigen-presenting cells, which may result in a heightened interaction with CD40L on T-cells, thereby enhancing its functional activity in T-cell priming. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin influences the NF-κB pathway, which is involved in the expression of CD40L. By modulating this pathway, quercetin can lead to an upregulation of CD40L expression on activated T-cells, indirectly enhancing its functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to enhance the expression of CD40L through its action on NF-κB and AP-1 transcription factors, which are involved in T-cell activation and thereby could enhance the functional activity of CD40L in immune responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane affects the NF-κB pathway, which is instrumental in regulating immune responses including the expression of CD40L. By modulating this pathway, sulforaphane may indirectly promote CD40L-mediated T-cell interactions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can modulate T-cell activity and has been shown to affect the expression of various co-stimulatory molecules. It may enhance CD40L activity by influencing T-cell receptor signaling, leading to increased CD40L expression on the T-cell surface, enhancing its immunological functions. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A induces the expression of CD40L by activating the transcription factor NF-κB in T-cells, which plays a crucial role in the regulation of immune responses and could thereby enhance the functional activity of CD40L. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid is known to modulate NF-κB signaling. By influencing this pathway, it may upregulate the expression of CD40L on T-cells, enhancing its activity in initiating and sustaining immune responses. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol affects the NF-κB pathway, which can lead to increased expression of CD40L on T-cells. This enhancement of CD40L activity can contribute to its role in T-cell and B-cell interactions, essential for immune response. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Fisetin modulates several signaling pathways, including NF-κB, which are implicated in T-cell activation and CD40L expression. By these means, fisetin could indirectly enhance the activity of CD40L in the immune system. | ||||||