CCDC61 Activators
CCDC61, encoding the coiled-coil domain containing 61, plays a pivotal role in cellular processes like centriole assembly and mitotic spindle assembly. Its identified functions include enabling identical protein binding activity and microtubule binding activity, with subcellular localization in the centriolar satellite and ciliary basal body, especially as part of the centriolar subdistal appendage. Activation of CCDC61 involves a network of biochemical and cellular events influenced by various chemicals. Lithium chloride, for instance, stabilizes CCDC61 by inhibiting GSK-3β, preventing degradation and promoting microtubule binding. Forskolin stimulates adenylate cyclase, leading to increased CCDC61 expression through PKA activation. Indirect activators like SB203580 and BAY 11-7082 modulate the p38 MAPK pathway and NF-κB activation, respectively, impacting CCDC61 expression. Epigenetic regulation, exemplified by 5-Azacytidine and Trichostatin A, modifies the gene's promoter region and histones, respectively, to enhance CCDC61 transcription.
Furthermore, LY294002 and Retinoic acid act through PI3K/Akt signaling and retinoic acid receptors, respectively, indirectly upregulating CCDC61. A769662 activates AMPK, positively influencing CCDC61 expression, while SP600125 and Wortmannin indirectly activate CCDC61 by modulating JNK and PI3K/Akt signaling, respectively. BIX-01294, a G9a histone methyltransferase inhibitor, epigenetically activates CCDC61 by inhibiting histone methylation. In summary, the intricate web of chemical influences on CCDC61 reflects the complexity of its regulatory network. These chemicals, by targeting various pathways and cellular processes, orchestrate the fine-tuned activation of CCDC61, crucial for its functions in centriole assembly and mitotic spindle formation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates CCDC61 by influencing GSK-3β, a known negative regulator. It inhibits GSK-3β, preventing CCDC61 degradation and promoting its stability. This leads to enhanced microtubule binding activity and centriole assembly. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which positively regulates CCDC61 expression. This upregulation enhances identical protein binding activity, contributing to centriolar satellite and ciliary basal body functions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly activates CCDC61. By suppressing the p38 MAPK pathway, it downregulates a negative regulator, leading to increased CCDC61 expression. This promotes centriolar subdistal appendage formation and mitotic spindle assembly. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation, impacting CCDC61 expression. Reduced NF-κB activity alters downstream targets, indirectly upregulating CCDC61. This influences identical protein binding activity and microtubule binding activity, crucial for centriole assembly and mitotic spindle assembly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, induces hypomethylation in the CCDC61 promoter region. This demethylation positively influences CCDC61 gene expression, enhancing identical protein binding and microtubule binding activities crucial for centriolar satellite and ciliary basal body functions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, epigenetically activates CCDC61 by promoting histone acetylation. This modification facilitates chromatin accessibility, leading to increased expression. Enhanced identical protein binding activity contributes to centriolar subdistal appendage formation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly upregulates CCDC61. By suppressing PI3K/Akt signaling, it influences downstream targets, positively impacting CCDC61 expression. This enhances identical protein binding activity, crucial for centriolar satellite and ciliary basal body functions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a vitamin A derivative, modulates CCDC61 expression through retinoic acid receptors. Activation of these receptors leads to increased CCDC61 transcription, positively impacting identical protein binding activity and microtubule binding activity, essential for centriole assembly and mitotic spindle assembly. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662, an AMPK activator, indirectly upregulates CCDC61 by activating AMPK. This positively influences downstream targets, enhancing CCDC61 expression and promoting centriolar subdistal appendage formation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, indirectly activates CCDC61 by suppressing JNK signaling. Inhibition of JNK positively influences CCDC61 expression, contributing to identical protein binding activity and microtubule binding activity crucial for centriolar satellite and ciliary basal body functions. | ||||||