Cbl-3 Activators
Cbl-3 Activators represent a diverse group of compounds that indirectly enhance the ubiquitin ligase activity of Cbl-3, a protein that orchestrates the ubiquitination and subsequent degradation of various cellular substrates. Compounds like Epigallocatechin gallate, Forskolin, and Genistein exert their influence by modifying the phosphorylation state of proteins within the cell, either through inhibition of kinases or activation of signaling pathways that converge on substrates of Cbl-3, thereby enhancing its ubiquitination scope. Curcumin, Resveratrol, and Quercetin alter multiple cellular processes, including kinase activity regulation and modulation of oxidative stress, which could indirectly enhance the functional activity of Cbl-3 by changing the modification states of proteins that Cbl-3 targets for ubiquitination. PD 98059, as a MEK inhibitor, and LY294002, as a PI3K inhibitor, may stabilize and increase the pool of proteins available for Cbl-3-mediated ubiquitination, thus enhancing the ubiquitin ligase activity of Cbl-3.
Additionally, Piperine and Capsaicin may influence the post-translational modification of proteins and intracellular calcium levels, respectively, which can lead to an enhanced activation state of Cbl-3. Sulforaphane's interaction with NF-κB signaling and Rapamycin's inhibition of mTOR are also critical, as they may affect the turnover and degradation of proteins that are potential substrates for Cbl-3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione can increase intracellular zinc levels, which may stabilize Cbl-3 by enhancing its zinc finger domain, essential for its ubiquitin ligase activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90, inhibiting its chaperone function. This disruption can lead to the degradation of negative regulators of Cbl-3, thereby enhancing Cbl-3's ubiquitin ligase activity. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper can indirectly enhance Cbl-3 by affecting phosphorylation states of cellular proteins, potentially including substrates of Cbl-3, enhancing its ubiquitination activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can increase the levels of ubiquitinated proteins. This accumulation can saturate ubiquitin-binding domains of proteasomes, potentially enhancing Cbl-3-mediated ubiquitination by increasing available ubiquitin. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate acts as a phosphatase inhibitor, which could enhance Cbl-3 activity by preventing the dephosphorylation of proteins involved in the Cbl-3 regulated pathways, maintaining the pathway in an activated state. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, which could enhance Cbl-3 by preventing the dephosphorylation and inactivation of Cbl-3 substrates, thereby maintaining Cbl-3's ubiquitination activity. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A is a farnesyltransferase inhibitor which could prevent the farnesylation of Cbl-3, enhancing its membrane localization and interaction with substrates, leading to increased ubiquitin ligase activity. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K-252a inhibits protein kinase C, which could enhance Cbl-3's activity by increasing the phosphorylation of substrates that Cbl-3 targets, potentially leading to enhanced ubiquitin ligase activity of Cbl-3. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 inhibits cysteine proteases, which could lead to the accumulation of proteins that are normally degraded. This accumulation may enhance Cbl-3 activity by increasing the pool of substrates available for ubiquitination by Cbl-3. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor which could enhance Cbl-3 activity by causing an accumulation of ubiquitinated proteins, which may include regulatory proteins that control Cbl-3 activity, potentially leading to a more active Cbl-3. | ||||||