ARHGAP4 Activators
ARHGAP4 Activators are a group of compounds that act by influencing the protein kinase C (PKC) pathway and the adenylate cyclase-cAMP-EPAC-Rap1 pathway. ARHGAP4 is a member of the Rho GTPase activating proteins (GAPs), which are implicated in various biological processes including the regulation of small GTPases such as Rap1. The PKC pathway is one of the pathways known to regulate GAPs. Phorbol 12-myristate 13-acetate (PMA), Bryostatin 1, and DAG are PKC activators that can enhance the functional activity of ARHGAP4 by activating PKC.
The second group of compounds that can activate ARHGAP4 are those that influence the adenylate cyclase-cAMP-EPAC-Rap1 pathway. Adenylate cyclase, the enzyme responsible for converting ATP to cAMP, and phosphodiesterases, the enzymesresponsible for degrading cAMP, play crucial roles in controlling the levels of cAMP, a secondary messenger. Increasing the levels of cAMP can activate EPAC, which in turn activates Rap1, a small GTPase. ARHGAP4 is known to interact with Rap1, hence, compounds that can increase the levels of cAMP such as Prostaglandin E1 (PGE1), Forskolin, 8-Bromo-cAMP, IBMX, Cloprostenol, Isoproterenol, Iloprost, Terbutaline, and Albuterol, can indirectly enhance the functional activity of ARHGAP4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a protein kinase C (PKC) activator. ARHGAP4, as a GTPase activating protein (GAP), is known to be regulated by PKC. Thus, by activating PKC, PMA can enhance the functional activity of ARHGAP4. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is another PKC activator. It can enhance ARHGAP4 activity by activating PKC, which is known to regulate GAPs like ARHGAP4. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DAG is a PKC activator that can bind and activate PKC, leading to the enhanced activity of ARHGAP4, as GAPs like ARHGAP4 are regulated by PKC. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
PGE1 activates adenylate cyclase, which increases cAMP levels. This can lead to the activation of EPAC, a direct activator of Rap1, a small GTPase. ARHGAP4 is known to interact with Rap1, and thus PGE1 indirectly activates ARHGAP4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can activate EPAC and subsequently Rap1. As ARHGAP4 is known to interact with Rap1, forskolin indirectly enhances the functional activity of ARHGAP4. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog used to activate cAMP-dependent pathways. It can activate EPAC and subsequently Rap1, a known interactor of ARHGAP4, therefore indirectly enhancing ARHGAP4 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which break down cAMP. By inhibiting these enzymes, IBMX increases the level of cAMP, which can subsequently activate EPAC and Rap1, indirectly enhancing ARHGAP4 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that activates adenylate cyclase, leading to increased cAMP levels. This can activate EPAC and subsequently Rap1, indirectly enhancing ARHGAP4 activity. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost is a potent and stable analog of prostacyclin that can activate adenylate cyclase, increasing cAMP levels, which can activate EPAC and subsequently Rap1, indirectly enhancing ARHGAP4 activity. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist that activates adenylate cyclase, leading to increased cAMP levels. This can activate EPAC and subsequently Rap1, indirectly enhancing ARHGAP4 activity. | ||||||