ARHGAP4 Inhibitors
ARHGAP4 inhibitors belong to a chemical class of compounds that specifically target the Rho GTPase-activating protein 4 (ARHGAP4). Rho GTPases are a family of small GTP-binding proteins that play essential roles in regulating various cellular processes, including cytoskeleton dynamics, cell migration, and cell adhesion. ARHGAP4 acts as a negative regulator of Rho GTPases by facilitating the hydrolysis of GTP to GDP, leading to their inactivation.
By inhibiting ARHGAP4, these compounds may interfere with its ability to regulate Rho GTPases, thereby potentially impacting downstream cellular functions. Rho GTPases are key mediators of signal transduction pathways, and dysregulation of their activity is associated with various diseases, including cancer and neurological disorders. Studying ARHGAP4 inhibitors provides valuable insights into the intricate mechanisms of Rho GTPase signaling and its relevance to cellular physiology and disease pathogenesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Fasudil is an approved drug that inhibits Rho kinase (ROCK), a downstream effector of Rho GTPases. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is another ROCK inhibitor that may impact Rho GTPase signaling. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC23766 is a specific inhibitor of Rac1, a member of the Rho GTPase family. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin and its derivative G04 have been identified as selective inhibitors of RhoA activation. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is a compound that selectively inhibits Rac1 activation. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
CASIN is a selective inhibitor of Cdc42 GTPase. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is an inhibitor of the Wiskott-Aldrich syndrome protein (WASP), which regulates actin polymerization downstream of Cdc42 and Rac1. | ||||||