Molecular structure of Wiskostatin, CAS Number: 1223397-11-2
Wiskostatin (CAS 253449-04-6)
See product citations (4)
Alternate Names:
1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol
Application:
Wiskostatin is a selective inhibitor of actin filament assembly
CAS Number:
253449-04-6
Molecular Weight:
426.15
Molecular Formula:
C17H18Br2N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Wiskostatin is a selective inhibitor of the actin-binding protein N-WASP, which is involved in actin polymerization and cytoskeleton reorganization. This compound is valuable in cell biology research for studying the dynamics of actin assembly and its role in processes such as cell motility, adhesion, and morphology. By inhibiting N-WASP activity, Wiskostatin allows researchers to dissect the contribution of N-WASP to the formation of actin-rich structures like filopodia and lamellipodia. It is also employed in the investigation of intracellular trafficking and signal transduction pathways that are regulated by actin cytoskeletal rearrangements. Furthermore, Wiskostatin is used to gain insights into the pathophysiology of conditions where aberrant regulation of actin polymerization is a factor.
Wiskostatin (CAS 253449-04-6) References
- Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. | Peterson, JR. and Mitchison, TJ. 2002. Chem Biol. 9: 1275-85. PMID: 12498880
- Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. | Peterson, JR., et al. 2004. Nat Struct Mol Biol. 11: 747-55. PMID: 15235593
- CFTR surface expression and chloride currents are decreased by inhibitors of N-WASP and actin polymerization. | Ganeshan, R., et al. 2007. Biochim Biophys Acta. 1773: 192-200. PMID: 17084917
- N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. | Guerriero, CJ. and Weisz, OA. 2007. Am J Physiol Cell Physiol. 292: C1562-6. PMID: 17092993
- Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway. | Bompard, G., et al. 2008. BMC Cell Biol. 9: 42. PMID: 18667055
- Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. | Inoue, T., et al. 2010. Exp Eye Res. 90: 360-7. PMID: 19961849
- Impact of the carbazole derivative wiskostatin on mechanical stability and dynamics of motile cells. | Pfannes, EK., et al. 2012. J Muscle Res Cell Motil. 33: 95-106. PMID: 22407517
- Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways. | Escudero-Esparza, A., et al. 2012. J Exp Clin Cancer Res. 31: 43. PMID: 22559840
- Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. | Guenin-Macé, L., et al. 2013. J Clin Invest. 123: 1501-12. PMID: 23549080
- The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na(+) transport in frog skin. | Krutetskaya, ZI., et al. 2016. Dokl Biochem Biophys. 467: 102-4. PMID: 27193709
- Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion. | Frugtniet, BA., et al. 2017. BMC Cancer. 17: 224. PMID: 28351346
- Inhibition of N-WASP affects actin-mediated cytokinesis during porcine oocyte maturation. | Wang, QC., et al. 2020. Theriogenology. 144: 132-138. PMID: 31940504
- Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells. | Yoshihara, M., et al. 2020. Exp Cell Res. 392: 112011. PMID: 32339607
- Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. | Wen, D., et al. 2022. Microbes Infect. 24: 104931. PMID: 35026388
- Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. | Cossar, PJ., et al. 2023. Eur J Med Chem. 247: 115001. PMID: 36577213
Inhibitor of:
α-actinin-4, β1-Syntrophin, ζ2-COP, 3110003A17Rik, 4921528I01Rik, 4922505E12Rik, 5830411N06Rik, 6230427J02Rik, 6720456B07Rik, 9930023K05Rik, Abi-1, ABLIM1, Abp1, ACBD5, Aciculin, ACTL7B, ACTR10, ANG I, ANKRD13C, ANKRD23, AP1GBP1, ARFRP1, ARGFX, ARHGAP4, ARL15, ARMCX5, Arp2, Arp3β, BET3L, BTBD8, C14orf132, C14orf178, C14orf82, C16orf13_0610011F06Rik, C19orf64, C1orf100_1700016C15Rik, C1orf101, C1orf116, C1orf144, C1orf227, C1orf93, C2orf44_BC068281, C3orf18, C3orf45, C3orf56, C5orf54, C7orf38, Calponin 2, CAP1, CCDC110, CCDC18, CCDC82, CCRL2, Cdc42EP2, ChREBP, claudin-11, Cofilin 1, Cofilin 2, COPZ, Cordon-bleu, Coronin 1A, Coronin 2A, Coronin 2B, Coronin 6, CYFIP2, DENND2C, DIAPH3, DNTNP, DOCK 6, DTHD1, Dynlt3, E130112L23Rik, Elmo1, EPB41L5, Espin, ETV3L, EVL, FAM115C, FAM131B, FAM154B, FAM160A2, FAM161A, FAM184B, FAM21A, FAM39E, FAM9A, FBLIM1, FCGBP_Fcgbp, FGGY, Filamin 1, Filamin 3, FLJ31485, FOG-2, FOXO3, Frabin, GAGE2E, GCP-2, GDC, GGA3, GIPC3, GK3P, Gle1, Glut1, Glut10, Glut11, Glut14, Glut2, Glut3, Glut4, Glut5, Glut7, Gm732, GPS2, GPSM3, hemicentin-1, HepaCAM, Hex, HIP-55, HLA-HB1, HMP-2, hnRNP E3, HSPC300, HXK I, HXK II, HXK III, IER2, IQGAP2, KIAA0040, KIAA0922_mKIAA0922, KIAA1033, KLHDC9, Lad, Lamellipodin, Lbc, LCA5, LDLRAD1, Leiomodin 3, LIN-10, LMO7, LOC283129, LOC374920_6330408A02Rik, LOC644012, LOC728741, LOC729562, LPP, LRRC16B, LRRC29, LRRC30, LRRC34, LRRC40, LSP1, LURAP1, LUZP1, MAGI-1, MAGI-2, MICAL1, Mlx, MORN1, MOSPD2, MrgB13, MRTF-B, MSAP, Muscle Actin, MYH8, MyoD, Myoferlin, myopalladin, Myosin Ic, Myosin Vb, Myosin XVIIIb, Myosin-neonatal, N-WASP, NaGLT1, Naglt1c, Ndfip2, Nebulin, Neurensin-1, Neuroplastin, Nir2, NKG7, NPAP1, NYAP2, ORF19, Otoraplin, palladin, PANK4, PAQR4, PCDH1_Pcdh1, PCDHB11, Pcdhb17, PDCL3, PDZ-GEF1, periaxin, Pit-1, plakophilin 4, PLP2, POF1B, Polycystin-1L1, POP1, Profilin-2, PSD, Punc, R9AP, Rab 4A, Rab 6A, Rab 9B, RAPGEF5, RBMY1A, RGS7 (regulator of G protein signaling), Rhox3f, RILPL2, RIM-BP2, RIN3, SCAMP5, SCARA5, Seh1, SH2D (SH2 domain containing protein), SHD1, SHROOM1, SHROOM4, Sidekick-1, SIM1, SIMC1, Skint11, SLC-1, SLC2A4RG, SLC35F4, SLC37A3, SLC43A1, SLITRK4, SMIM23, SNAPC 50, SNAT6, SNX5, SPACA1, SPACA4, SPATA7, Spir-1, SPT20L2, Strumpellin, SUCO, SUN1, Supervillin, SYAP1, Syne-3, Syntaxin 12, T-Plastin, Tβ-15a, TESSP3, TEX10, TGaseZ, THAP5, TIM-4, TMEM104, TMEM167, TMEM170, TMEM192, TMEM248, TMEM29, TMEM31, TMEM53, TMEM89, TOCA-1, TRAPPC10, TRAPPC5, Tropomyosin, Tropomyosin β, TTLL13, UBAP1, UBPH, URB2, V1RD14, Vav3, VIPAR, Vmn2r92, VPS26B, VPS45, VPS51, VWA5B1, VWC2L, WAVE1, WDR26, Wip1, WRCH1, Xinα, Xinβ, ZBBX_FLJ23049, ZFP873, ZFP94, ZNF626, ZNF642, and ZNF665.Activator of:
γ Enolase, γ2-COP, ABLIM1, AIP5, ARFGAP1, ARHGAP15, ARL4D, CD72, Cdc42EP4, CED-5, COG3, COPB, Coronin 6, DDEFL1, Dia 1, Eph A8, FAM38B, FCHSD1, FGD1, FGF-11, FMNL1, FNBP2, FNBP3, Gm732, Gm996, GMF-β, GOLGA6A-D, KRAP, Las17, Leiomodin 1, Liprin β2, Myosin XVIIIa, Myosin-13, NECAP 2, NHS, Nup50, p41-ARCb, PHLDB1, PLEKHG6, plexin-A2, POSH, Rab 19, Rab 20, Rab 2A, Rab 30, Rab 8A, SPATA13, SYDE1, Syne-2, tropomodulin 4, WDR47, and YIPF6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wiskostatin, 1 mg | sc-204399 | 1 mg | $48.00 | |||
Wiskostatin, 5 mg | sc-204399A | 5 mg | $122.00 | |||
Wiskostatin, 25 mg | sc-204399B | 25 mg | $432.00 | |||
Wiskostatin, 50 mg | sc-204399C | 50 mg | $812.00 |