Fasudil, Monohydrochloride Salt (CAS 105628-07-7)
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Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.
Fasudil, Monohydrochloride Salt (CAS 105628-07-7) References
- Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression. | Kanazawa, I., et al. 2010. Endocr J. 57: 415-21. PMID: 20154408
- Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway. | Li, Y., et al. 2010. Med Sci Monit. 16: BR112-118. PMID: 20357711
- Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure. | Fujimura, M., et al. 2011. Toxicol Appl Pharmacol. 250: 1-9. PMID: 20869980
- Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice. | Ding, J., et al. 2010. J Neurochem. 114: 1619-29. PMID: 20882700
- ROCK1 feedback regulation of the upstream small GTPase RhoA. | Tang, AT., et al. 2012. Cell Signal. 24: 1375-80. PMID: 22430126
- Rho-ROCK and Rac-PAK signaling pathways have opposing effects on the cell-to-cell spread of Marek's Disease Virus. | Richerioux, N., et al. 2012. PLoS One. 7: e44072. PMID: 22952878
- Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. | Llavero Hurtado, M., et al. 2017. Sci Rep. 7: 12412. PMID: 28963550
- Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. | Takase, S., et al. 2022. Eur J Pharmacol. 931: 175207. PMID: 35987254
- Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene. | Tanaka, R., et al. 2023. Pharmacol Res. 187: 106589. PMID: 36462727
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fasudil, Monohydrochloride Salt, 10 mg | sc-203418 | 10 mg | $18.00 | |||
Fasudil, Monohydrochloride Salt, 50 mg | sc-203418A | 50 mg | $32.00 | |||
Fasudil, Monohydrochloride Salt, 250 mg | sc-203418B | 250 mg | $85.00 | |||
Fasudil, Monohydrochloride Salt, 1 g | sc-203418C | 1 g | $165.00 | |||
Fasudil, Monohydrochloride Salt, 2 g | sc-203418D | 2 g | $248.00 | |||
Fasudil, Monohydrochloride Salt, 5 g | sc-203418E | 5 g | $486.00 | |||
Fasudil, Monohydrochloride Salt, 10 g | sc-203418F | 10 g | $910.00 |