Molecular structure of Terbutaline Hemisulfate, CAS Number: 23031-32-5
Terbutaline Hemisulfate (CAS 23031-32-5)
See product citations (2)
Alternate Names:
Bricanyl
Application:
Terbutaline Hemisulfate is an agonist at β2-adrenergic receptors
CAS Number:
23031-32-5
Purity:
≥98%
Molecular Weight:
274.32
Molecular Formula:
C12H19NO3•1/2(H2SO4)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Terbutaline is a β2-adrenergic receptor agonist that functions as a bronchodilator. It acts by binding to the β2-adrenergic receptors on smooth muscle cells in the airways, leading to the activation of adenylate cyclase and subsequent increase in intracellular cyclic AMP levels. This results in the relaxation of bronchial smooth muscle, leading to bronchodilation and improved airflow in the lungs. Terbutaline may inhibit the release of inflammatory mediators from mast cells, such as histamine and leukotrienes, which can contribute to bronchoconstriction. At the molecular level, Terbutaline′s interaction with β2-adrenergic receptors leads to a cascade of intracellular events that ultimately result in the relaxation of bronchial smooth muscle, making it for studying the regulation of airway smooth muscle tone in experimental applications.
Terbutaline Hemisulfate (CAS 23031-32-5) References
- Simple method for determination of terbutaline plasma concentration by high-performance liquid chromatography. | Herring, VL. and Johnson, JA. 2000. J Chromatogr B Biomed Sci Appl. 741: 307-12. PMID: 10872601
- Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. | Planès, C., et al. 2002. J Biol Chem. 277: 47318-24. PMID: 12372821
- Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. | Aldridge, JE., et al. 2005. Toxicol Appl Pharmacol. 203: 132-44. PMID: 15710174
- Beta2-adrenoceptors: mechanisms of action of beta2-agonists. | Johnson, M. 2001. Paediatr Respir Rev. 2: 57-62. PMID: 16263481
- Terbutaline inhibits corticotropin-releasing hormone (CRH) expression in human trophoblast cells. | Kontopoulos, EV., et al. 2006. J Matern Fetal Neonatal Med. 19: 735-9. PMID: 17127497
- Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. | Zerrate, MC., et al. 2007. J Pharmacol Exp Ther. 322: 16-22. PMID: 17400887
- Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway. | Freund-Michel, VC., et al. 2010. Eur Respir J. 35: 647-54. PMID: 19679606
- Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism. | Bohren, Y., et al. 2013. Neurobiol Dis. 60: 39-50. PMID: 23978467
- Establishment of a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. | Koseki, N., et al. 2014. J Toxicol Sci. 39: 579-600. PMID: 25056783
- Status epilepticus increases mature granule cells in the molecular layer of the dentate gyrus in rats. | Liang, Z., et al. 2013. Neural Regen Res. 8: 609-15. PMID: 25206705
- Dendritic morphology, synaptic transmission, and activity of mature granule cells born following pilocarpine-induced status epilepticus in the rat. | Gao, F., et al. 2015. Front Cell Neurosci. 9: 384. PMID: 26500490
- Mice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures. | Brulet, R., et al. 2017. Exp Neurol. 293: 190-198. PMID: 28427858
- Enhancement of acute myocardial lesions by asthma drugs in rats. | Whitehurst, VE., et al. 1994. Toxicol Pathol. 22: 72-6. PMID: 7915431
- Terbutaline inhalation suppresses fentanyl-induced coughing. | Lui, PW., et al. 1996. Can J Anaesth. 43: 1216-9. PMID: 8955969
- Application of classical gel electrophoresis to the chiral separation of milligram quantities of terbutaline. | Stalcup, AM., et al. 1998. Anal Chem. 70: 144-8. PMID: 9435473
Inhibitor of:
beta1-AR.Activator of:
β2-AR, 1190002N15Rik, 1700034O15Rik, Ag2, APBA2BP, ARHGAP20, ARHGAP4, ARHGAP9, ARRDC2, ATP9BL, ATP9BL2, BAALC, Basal ciliated, Basonuclin 2, beta2-AR, C11orf70, C14orf143, C19orf35, CCDC105, CCDC153, CCDC60_Ccdc60, CCDC82, CCDC84, CCDC85C, CCDC9, CCDC91, CCDC94, CCDC97, CELSR3, CHSY2, CLDND2, CREBL2, D54, EG628705, ENDOD1, eoxtaxin-3, ETL, FAM118B, FAM228B_A830093I24Rik, GDE6, GHRH-R, Gm129, GNPTAB, GPATCH1, GPR-137, GPR-152, H2-Q1, HARBI1, HuC, KBTBD3, KCTD21, KDELC2, KLHL26, LMO3, LOC388564, MBD3L1, MBD3L5, Med29, METT5D1, MIPU1, MORN3, MPND, MRP-L34, MS4A13, MS4A3, MS4A6A, MYLPF, Nim1, NPS, NRK, OCEL1, Odf3, Olr1020, Olr104, Olr1059, Olr1061, Olr434, OR10A5, OR4A16, OR4C13, OR4C3, OR4D9, OR4P4, OR4X1, OR56A4, OR5B12, OR6K2, OR8B12, OR8G5, OR9Q2, OVCH1, OVCH2, PAAF1, PAC4, PC1, PDE7B, PGT, PHACTR2, PHKG2, PIH1D2, PLEKHH2, PRR9, PSG7, R9AP, Ramp4, REP15, RERGL, RFPL4B, RSHL1, Sarcalumenin, SCGB1D4, SDF-2L1, SEC14L1, sFlt-1, Skint9, SNX10, SPA-L3, SPRED2, SULT2A3, SULT2A6, TBCEL, TCP-10b, Tdpoz2, Tdpoz3, Tdpoz5, TDRD10, TDRD7, Tect1, Tenrl, TEX10, TEX16, TEX19.2, TMEM86B, TMEM9B, TPSB3, TRPT1, TTC9C, UBQLNL, V1RA4, V3R 2, VMAC, Vmn2r6, Vmn2r60, Vmn2r63, Vmn2r66, Vmn2r68, XLαs, YPEL4, and ZFPL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Terbutaline Hemisulfate, 1 g | sc-204911 | 1 g | $92.00 | |||
Terbutaline Hemisulfate, 5 g | sc-204911A | 5 g | $378.00 |