APOBEC3D Inhibitors
APOBEC3D inhibitors belong to a distinct chemical class designed to modulate the activity of the APOBEC3D enzyme, which is a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of proteins. APOBEC3D, along with other family members, plays a crucial role in the innate immune response against retroviruses and other genetic elements, such as retrotransposons and endogenous retroviruses. These enzymes are particularly known for their ability to deaminate cytidine to uridine in single-stranded DNA and RNA molecules. By catalyzing these deamination reactions, APOBEC3D can introduce mutations into the genetic material of viruses, rendering them non-functional or less virulent. APOBEC3D inhibitors are chemical compounds specifically designed to modulate the activity of APOBEC3D.
APOBEC3D inhibitors is driven by the need to dissect the intricate interplay between these enzymes and the viruses they target. Researchers seek to understand how APOBEC3D inhibitors can be utilized to control its mutagenic activity, thereby potentially preventing the genetic evolution of certain viruses. Additionally, these inhibitors can serve as valuable tools in elucidating the broader role of APOBEC proteins in genome defense and maintenance. The chemical class of APOBEC3D inhibitors encompasses various compounds that have been designed and tested for their ability to modulate APOBEC3D activity, with the ultimate goal of advancing our understanding of host-virus interactions and the potential implications for disease control and genomic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quinomycin A | 512-64-1 | sc-202306 | 1 mg | $163.00 | 4 | |
Quinomycin A is a quinoxaline antibiotic that binds to DNA and can indirectly affect APOBEC3D by altering its substrate availability or access. | ||||||
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $31.00 $47.00 $92.00 | 13 | |
This compound is known to inhibit nucleic acid enzymes and may interfere with the RNA binding capacity of APOBEC3D. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural product from turmeric, has been shown to modulate a variety of molecular targets and could alter APOBEC3D activity by modifying the enzyme's expression or interaction with RNA. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This green tea polyphenol has multiple targets within the cell and can affect the activity of nucleic acid-modifying enzymes, thereby possibly altering APOBEC3D activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a stilbenoid that influences numerous cellular pathways and might modulate the expression or activity of APOBEC3D through its effects on signaling pathways. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Although used as a tyrosine kinase inhibitor, Imatinib can affect various cellular processes and might influence APOBEC3D indirectly through its effects on cellular signaling. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
An antimalarial drug known to affect nucleic acid function and could potentially alter APOBEC3D's interaction with its RNA substrates or regulatory processes. | ||||||
Lamivudine | 134678-17-4 | sc-221830 sc-221830A | 10 mg 50 mg | $102.00 $214.00 | 1 | |
A nucleoside analogue that may affect the enzymatic activity of APOBEC3D by altering the availability or structure of its RNA substrates. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
An antiviral drug that has been shown to influence the mutation rate of viruses and might interact with APOBEC3D by modulating its ability to edit RNA. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
Another nucleoside analogue which could compete with the natural substrates of APOBEC3D, potentially affecting its enzymatic activity. | ||||||