Ribavirin is a non-interferon-inducing, broad spectrum antiviral nucleoside. Ribavirin is reported to be active against RSV, HIV, HCV, and other infectious agents. The compound's metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.
Li, W., et al. 1999. Oncol. Res. 11, 243. Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653. Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285. Kakumu, S., et al. 1993. Gastroenterology 105, 507. Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123. R: 61; S: 3/7/9-22-45-53
Reconstituted solutions should be prepared immediately before use or may be stored at 2 to 6°C up to 24 hours.
Soluble in water (20 mg/ml), DMSO (49 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and alcohol (slightly).
Store at 4° C
173° C (lit.)
639.78° C at 760 mmHg (Predicted)
2.09 g/cm3 (Predicted)
n20D 1.82 (Predicted)
α20/D -38°±3°, c = 1 in water
colony formation of primary AML-M5 progenitor cells: IC50 = ~1 µM; IMPDH: IC50 = 1 µM (mouse); IMPDH: IC50 = 1 µM (human); Influenza A virus: IC50 = 1.9 µM; growth of ovarian carcinoma OVCAR-5 cells: IC50 = 35 µM; growth of human myeloma 8226 cells: IC50 = 40 µM
active metabolite, ribavirin triphosphate: Ki= ~0.3 µM
pKa: 12.95 (Predicted), pKb: 0.21 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
How can I solve the powdered ribavirin ≥ 98% pure? thanks
Asked by: Elaheh
Thank you for your question. Ribavirin (CAS 36791-04-5) sc-203238 is soluble in water (20 mg/ml), DMSO (49 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and alcohol (slightly). For further information please contact our technical service team.
Rated 5 out of
ShiShi, F. et al. (PubMed 26317515) found that Ribavirin, a broad spectrum antiviral nucleoside, inhibits the activity of mTOR/eIF4E, ERK/Mnk1/eIF4E signaling pathway and synergizes with tyrosine kinase inhibitor Imatinib to impair Bcr-Abl mediated proliferation and apoptosis in Ph+ leukemia. -SCBT Publication Review
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