Aurintricarboxylic Acid (CAS 4431-00-9)
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Aurintricarboxylic Acid a cell-permeable polyanionic, polyaromatic compound employed as a powerful inhibitor of cellular processes, including apoptosis, that are dependent on the formation of protein-nucleic acid complexes. It binds to a FGF and reduces its angiogenic activity. Aurintricarboxylic Acid may act to inhibit apoptotic cell death in various cell types induced by a variety of factors. It has also been demonstrated to be a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that inhibits angiogenesis. Aurintricarboxylic Acid inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. Aurintricarboxylic Acid also stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cgamma and inhibits both major calpain isoforms (IC50 = 22 muM and IC50 = 10 muM for mu-calpain and m-calpain, respectively).
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Aurintricarboxylic Acid (CAS 4431-00-9) References
- RNA synthesis in isolated HeLa cell nuclei. | Sarma, MH., et al. 1976. Biochim Biophys Acta. 418: 29-38. PMID: 1244850
- Aurintricarboxylic Acid Decreases RNA Toxicity in a C. elegans Model of Repeat Expansions. | Braun, M., et al. 2021. Toxins (Basel). 13: PMID: 34941747
- Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex. | Che, K., et al. 2022. PLoS One. 17: e0266143. PMID: 35417479
- Characterization of Aurintricarboxylic Acid (ATA) Interactions with Plasma Transporter Protein and SARS-CoV-2 Viral Targets: Correlation of Functional Activity and Binding Energetics. | Minetti, CA., et al. 2022. Life (Basel). 12: PMID: 35743905
- Aurintricarboxylic acid protects isoproterenol induced left ventricular hypertrophy by modulating TWEAK signaling. | Burman, P., et al. 2022. Cardiovasc Pathol. 61: 107468. PMID: 35977688
- Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions. | González, RG., et al. 1980. Biochemistry. 19: 4299-303. PMID: 6158332
- A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells. | Okada, N. and Koizumi, S. 1995. J Biol Chem. 270: 16464-9. PMID: 7608219
- Aurintricarboxylic acid is an inhibitor of mu- and m-calpain. | Posner, A., et al. 1995. Biochem Mol Biol Int. 36: 291-9. PMID: 7663433
- Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells. | Benchokroun, Y., et al. 1995. Biochem Pharmacol. 49: 305-13. PMID: 7857317
- Tyrosine phosphorylation of ErbB4 is stimulated by aurintricarboxylic acid in human neuroblastoma SH-SY5Y cells. | Okada, N. and Koizumi, S. 1997. Biochem Biophys Res Commun. 230: 266-9. PMID: 9016763
- Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. | Rui, H., et al. 1998. J Biol Chem. 273: 28-32. PMID: 9417042
- Aurintricarboxylic acid prevents GLUR2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA1 neurons of gerbil after global ischemia. | Aronica, EM., et al. 1998. Proc Natl Acad Sci U S A. 95: 7115-20. PMID: 9618548
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aurintricarboxylic Acid, 100 mg | sc-3525 | 100 mg | $20.00 | |||
Aurintricarboxylic Acid, 1 g | sc-3525A | 1 g | $31.00 | |||
Aurintricarboxylic Acid, 5 g | sc-3525B | 5 g | $47.00 | |||
Aurintricarboxylic Acid, 10 g | sc-3525C | 10 g | $92.00 |