Molecular structure of Quinomycin A, CAS Number: 512-64-1
Quinomycin A (CAS 512-64-1)
See product citations (4)
Application:
Quinomycin A is an inhibitor of HIF
CAS Number:
512-64-1
Purity:
>99%
Molecular Weight:
1101.3
Molecular Formula:
C51H64N12O12S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quinomycin A is a cyclodepsipeptide metabolite of the quinoxaline family that exhibits various antibiotic, antiviral, and antitumor activity. Quinomycin A has been demonstrated to bind strongly to DNA at sites containing the central two-base-pair sequence 5#39-CG-3#39. Quinomycin A was observed to induce apoptosis in human colon cancer cells (HT-29) with activity associated with cytochrome c release and stimulations of ERK and caspase-3. Quinomycin A reportedly inhibits HIF by blocking binding of HIF-1alpha and HIF-1beta proteins to a HRE sequence, and by blocking hypoxic induction of luciferase in U251-HRE cells and VEGF mRNA expression in U251 cells.
Quinomycin A (CAS 512-64-1) References
- Identity of levomycin and quinomycin A (echimomycin). | KATAGIRI, K., et al. 1962. J Antibiot (Tokyo). 15: 273. PMID: 14042112
- Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. | Kong, D., et al. 2005. Cancer Res. 65: 9047-55. PMID: 16204079
- Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway. | Park, JY., et al. 2006. Int J Biochem Cell Biol. 38: 244-54. PMID: 16214385
- [Coculture of actinomycetes with Bacillus subtilis and its effect on the bioactive secondary metabolites]. | Huang, B., et al. 2009. Sheng Wu Gong Cheng Xue Bao. 25: 932-40. PMID: 19777825
- Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A. | Espinosa, A., et al. 2012. Parasitol Res. 111: 2473-7. PMID: 22763704
- Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity. | Hayase, H., et al. 2015. Biosci Biotechnol Biochem. 79: 633-5. PMID: 25471083
- Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells. | Ponnurangam, S., et al. 2016. Oncotarget. 7: 3217-32. PMID: 26673007
- Exploitation of Potentially New Antibiotics from Mangrove Actinobacteria in Maowei Sea by Combination of Multiple Discovery Strategies. | Lu, QP., et al. 2019. Antibiotics (Basel). 8: PMID: 31783564
- Quinomycin A reduces cyst progression in polycystic kidney disease. | Radadiya, PS., et al. 2021. FASEB J. 35: e21533. PMID: 33826787
- Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells. | Lafi, Z., et al. 2021. RSC Adv. 11: 29164-29177. PMID: 35479561
- Production of quinomycin A in Streptomyces lasaliensis. | Steinerová, N., et al. 1987. Folia Microbiol (Praha). 32: 1-5. PMID: 3817656
- Prevention of phage multiplication by quinomycin A. | Sato, K., et al. 1969. Biochim Biophys Acta. 174: 230-8. PMID: 4885693
- Echinomycin binding sites on DNA. | Van Dyke, MM. and Dervan, PB. 1984. Science. 225: 1122-7. PMID: 6089341
- Bifunctional intercalation and sequence specificity in the binding of quinomycin and triostin antibiotics to deoxyribonucleic acid. | Lee, JS. and Waring, MJ. 1978. Biochem J. 173: 115-28. PMID: 687363
- The binding of echinomycin to deoxyribonucleic acid. | Wakelin, SP. and Waring, MJ. 1976. Biochem J. 157: 721-40. PMID: 985413
Inhibitor of:
β-defensin 27, β-defensin 28, β-defensin 29, β-defensin 30, β-defensin 34, β-defensin 35, β-defensin 36, 2810403A07Rik, Aminopeptidase P1, APOBEC3D, APOBEC4, Arnt 2, EG666257, FOXD1, FOXD4L1, GGTase-IIβ, Gm22, GTF3A, H1T2, H3.Y Histone 2, HCFC1R1, HIF-1 alpha, HIF-3α, HMBOX1, HMGN3, Jaz, Kinocilin, Lipocalin-11, LOXL4, Morc, MTF-2, MUP18, PUS1, RBM35A, RFX8, Sox-14, SPIN1, TFIIIC220, THAP1, Tim13A/B, Tns, VHL, Wnt-8b, ZBRK1, ZIP1, ZNF133, ZNF154, ZNF313, ZNF589, ZNF654, and ZNF672.Activator of:
CA IX, HSF4, MTERF, and NPY2-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quinomycin A, 1 mg | sc-202306 | 1 mg | $166.00 |