ACOX1 Activators
ACOX1, or acyl-coenzyme A oxidase 1, stands as a pivotal player in peroxisomal fatty acid oxidation, intricately involved in maintaining cellular energy homeostasis and lipid metabolism. The diverse set of chemicals identified as ACOX1 activators underscores the multifaceted nature of the pathways modulating ACOX1 expression. Resveratrol, a polyphenol found in red grapes, emerges as an indirect activator of ACOX1. Its mechanism involves the enhancement of the SIRT1/AMPK pathway. By bolstering SIRT1 activity, resveratrol triggers AMPK activation, subsequently elevating ACOX1 expression through increased levels of PGC-1α. This intricate interplay exemplifies how cellular pathways involved in energy sensing can dynamically regulate ACOX1, highlighting resveratrol as a modulator of this finely tuned system. Clofibrate, a fibrate drug, takes a direct route in activating ACOX1 by binding to PPARα. This binding induces conformational changes in PPARα, facilitating its heterodimerization with RXR. The formed complex then binds to specific regions in the ACOX1 promoter, enhancing transcription and leading to the activation of ACOX1.
The chemical palette expands with C75, an inhibitor of fatty acid synthase (FAS), indirectly activating ACOX1 by redirecting cellular metabolism towards fatty acid oxidation. Inhibition of FAS by C75 diminishes endogenous fatty acid synthesis, pushing cells to rely more on fatty acid catabolism, consequently upregulating ACOX1 expression.The versatility continues with a set of PPAR agonists-GW7647, Bezafibrate, GW501516, and Wy-14643-each directly activating ACOX1 through the binding of PPARs and subsequent transcriptional initiation. Intriguingly, the AICAR and A769662 chemicals, both AMPK activators, indirectly activate ACOX1 by enhancing cellular energy status. Through AMPK-mediated phosphorylation and activation of PGC-1α, these compounds augment ACOX1 transcription, providing a link between cellular energy sensing and ACOX1 regulation. Although the exact mechanism remains under investigation, the observed increase in ACOX1 levels suggests a role for PFOA in influencing peroxisomal fatty acid oxidation through PPARα-mediated pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in red grapes, activates ACOX1 indirectly by modulating the SIRT1/AMPK pathway. Resveratrol enhances SIRT1 activity, leading to AMPK activation, which subsequently upregulates ACOX1 expression through increased PGC-1α levels. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate, a fibrate drug, directly activates ACOX1 by binding to PPARα. This interaction induces conformational changes in PPARα, facilitating its heterodimerization with RXR and subsequent binding to ACOX1 promoter regions, resulting in enhanced transcription and ACOX1 activation. | ||||||
C75 (racemic) | 191282-48-1 | sc-202511 sc-202511A sc-202511B | 1 mg 5 mg 10 mg | $71.00 $202.00 $284.00 | 9 | |
C75, an inhibitor of fatty acid synthase (FAS), indirectly activates ACOX1 by redirecting cellular metabolism towards fatty acid oxidation. By inhibiting FAS, C75 reduces endogenous fatty acid synthesis, promoting reliance on fatty acid catabolism and thereby enhancing ACOX1 expression to support increased lipid breakdown. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
GW7647, a selective PPARδ agonist, directly activates ACOX1 by binding to PPARδ and forming a transcriptionally active heterodimer with RXR. This complex binds to PPAR response elements in the ACOX1 promoter, promoting transcription and subsequent ACOX1 activation. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate, a fibrate drug, acts as a dual agonist for PPARα and PPARγ, leading to ACOX1 activation. The activation is mediated by PPARα binding to ACOX1 promoter regions and initiating transcription, while PPARγ enhances this effect by promoting PPARα expression and activity. This dual activation results in increased ACOX1 expression and enhanced fatty acid oxidation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR, an AMP-activated protein kinase (AMPK) activator, indirectly activates ACOX1 by enhancing cellular energy status. AICAR activates AMPK, which in turn phosphorylates and activates PGC-1α, a key regulator of ACOX1 expression. Increased PGC-1α levels promote ACOX1 transcription and subsequent activation, linking AMPK-mediated energy sensing to ACOX1 upregulation. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
OEA, an endogenous lipid mediator, activates ACOX1 indirectly by binding to PPARα. Upon binding, OEA induces a conformational change in PPARα, facilitating its heterodimerization with RXR and subsequent binding to ACOX1 promoter regions. This interaction leads to increased ACOX1 transcription and activation, highlighting the role of endogenous lipid signaling in modulating ACOX1 expression. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516, a selective PPARδ agonist, directly activates ACOX1 by binding to PPARδ and forming a transcriptionally active heterodimer with RXR. This complex binds to PPAR response elements in the ACOX1 promoter, promoting transcription and subsequent ACOX1 activation. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662, an AMPK activator, indirectly activates ACOX1 by enhancing cellular energy status. A769662 activates AMPK, leading to the phosphorylation and activation of PGC-1α, a key regulator of ACOX1 expression. Elevated PGC-1α levels promote ACOX1 transcription and subsequent activation, linking AMPK-mediated energy sensing to ACOX1 upregulation. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
Wy-14643, a PPARα agonist, directly activates ACOX1 by binding to PPARα and initiating transcription. The formed PPARα/RXR heterodimer binds to ACOX1 promoter regions, enhancing transcription and subsequent ACOX1 activation. | ||||||