ACOX1 Antibody (153CT43.1.1): sc-517306
- ACOX1 Antibody (153CT43.1.1) is a mouse monoclonal IgG1 ACOX1 antibody, cited in 6 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to ACOX1 of human origin
- recommended for detection of ACOX1 of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACOX1 Antibody (153CT43.1.1). This work is in progress.
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ACOX1 Antibody (153CT43.1.1) is a mouse monoclonal IgG1 antibody that detects ACOX1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-ACOX1 antibody (153CT43.1.1) is available as the non-conjugated format. ACOX1, or acyl-coenzyme A oxidase 1, is a crucial 660 amino acid protein localized in the peroxisome, where ACOX1 plays a vital role in lipid metabolism. Specifically, ACOX1 catalyzes the desaturation of very long chain acyl-CoA substrates into 2-trans-enoyl-CoA, a reaction that is essential for the breakdown of fatty acids and involves the use of FAD as a cofactor. This enzymatic activity not only facilitates energy production but also contributes to the regulation of cellular lipid levels, which is critical for maintaining cellular homeostasis. Defects in ACOX1 can lead to pseudoneonatal adrenoleukodystrophy (pseudo-NALD), a serious condition characterized by neurological impairments and metabolic dysfunctions, underscoring ACOX1′s significance in human health.
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ACOX1 Antibody (153CT43.1.1) References:
- Catalase-less peroxisomes. Implication in the milder forms of peroxisome biogenesis disorder. | Fujiwara, C., et al. 2000. J Biol Chem. 275: 37271-7. PMID: 10960480
- Peroxisomal acyl CoA oxidase deficiency. | Suzuki, Y., et al. 2002. J Pediatr. 140: 128-30. PMID: 11815777
- Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. | Ferdinandusse, S., et al. 2007. Hum Mutat. 28: 904-12. PMID: 17458872
- Peroxisomal acyl-CoA-oxidase deficiency: two new cases. | Carrozzo, R., et al. 2008. Am J Med Genet A. 146A: 1676-81. PMID: 18536048
- SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. | Chen, XF., et al. 2018. EMBO Rep. 19: PMID: 29491006
- Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. | Chung, HL., et al. 2020. Neuron. 106: 589-606.e6. PMID: 32169171
- Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression. | Zhang, Q., et al. 2023. Cell Discov. 9: 26. PMID: 36878899
- Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. | Lu, D., et al. 2024. Nat Commun. 15: 4214. PMID: 38760332
- Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase. | Aoyama, T., et al. 1994. Biochem Biophys Res Commun. 198: 1113-8. PMID: 8117268
- Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization. | Varanasi, U., et al. 1994. Proc Natl Acad Sci U S A. 91: 3107-11. PMID: 8159712
- Biochemical properties of liver peroxisomes from rat, guinea pig and human species and the influence of hormonal status on rat liver acyl-CoA oxidase mRNA content. | Pacot, C. and Latruffe, N. 1993. Biochimie. 75: 235-42. PMID: 8507686
- Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. | Fan, CY., et al. 1996. J Biol Chem. 271: 24698-710. PMID: 8798738
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACOX1 Antibody (153CT43.1.1) | sc-517306 | 100 µg/ml | $322.00 |