ACOX1 Inhibitors
Acyl-CoA oxidase 1 (ACOX1) is a key enzyme in the peroxisomal fatty acid β-oxidation pathway, primarily responsible for the catabolism of very-long-chain fatty acids. By catalyzing the first and rate-limiting step in this pathway, ACOX1 initiates the desaturation of acyl-CoA esters, generating hydrogen peroxide in the process. This enzyme plays a crucial role in lipid metabolism, contributing to energy homeostasis, and the maintenance of cellular lipid balance. The activity of ACOX1 is essential for the breakdown of fatty acids, whichn can lead to toxic effects within cells. The regulation of ACOX1 activity ensures the efficient processing of fatty acids, hindering their harmful buildup and supporting the generation of acetyl-CoA, which enters the citric acid cycle for energy production. Given its central role in fatty acid metabolism, ACOX1's function impacts various physiological processes, including thermogenesis, energy expenditure, and the synthesis of lipid-derived signaling molecules.
The inhibition of ACOX1 can occur through several mechanisms, affecting the enzyme's activity and, consequently, the peroxisomal β-oxidation pathway. Chemical inhibitors of ACOX1 may bind directly to the enzyme, altering its conformation and reducing its affinity for substrate or co-factors required for its catalytic activity. Such inhibition can lead to the accumulation of very-long-chain fatty acids, with implications for cellular function and metabolic health. Furthermore, genetic mutations or alterations in the expression of ACOX1 can also result in diminished enzyme activity, contributing to metabolic disorders characterized by disrupted lipid metabolism. Understanding the mechanisms underlying ACOX1 inhibition is critical for elucidating the pathophysiology of related metabolic conditions and for exploring interventions aimed at modulating fatty acid metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $149.00 $826.00 | 14 | |
Triacsin C is a potent inhibitor of long-chain acyl-CoA synthetases, including ACOX1. By preventing the activation of fatty acids, Triacsin C indirectly inhibits ACOX1, which is involved in the peroxisomal β-oxidation of fatty acids. Triacsin C acts at the initial step of the fatty acid metabolism pathway, impacting ACOX1 function by limiting its substrate availability. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine, an antipsychotic drug, has been identified as an inhibitor of ACOX1. It is proposed to modulate the activity of ACOX1 by affecting the peroxisomal function. Thioridazine's impact on ACOX1 might involve alterations in peroxisomal lipid metabolism, influencing the cellular levels of fatty acids and the subsequent activity of ACOX1 in the β-oxidation pathway within peroxisomes. | ||||||
Clofibric acid | 882-09-7 | sc-203000 sc-203000A | 10 g 50 g | $24.00 $39.00 | 1 | |
Clofibric Acid is a fibrate drug known for its lipid-lowering effects. It has been recognized as an inhibitor of ACOX1, potentially acting by modulating peroxisomal β-oxidation. Clofibric Acid's influence on ACOX1 may involve the regulation of lipid metabolism, impacting the availability of fatty acids for ACOX1-mediated β-oxidation processes within peroxisomes. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $148.00 $496.00 | 3 | |
Etomoxir is a specific irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT-1), an enzyme involved in fatty acid transport into mitochondria. By blocking fatty acid entry into mitochondria, Etomoxir indirectly inhibits ACOX1, which operates in peroxisomes. The inhibition of mitochondrial fatty acid oxidation impacts peroxisomal β-oxidation by altering the availability of specific substrates, affecting ACOX1 function. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole, an antifungal drug, has been identified as an inhibitor of ACOX1. The mechanism of ACOX1 inhibition by Miconazole is not fully elucidated but is likely related to its impact on peroxisomal function. Miconazole's influence on ACOX1 may involve alterations in peroxisomal lipid metabolism, affecting the availability of fatty acids for ACOX1-mediated β-oxidation processes within peroxisomes. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
Sodium phenylbutyrate is a derivative of butyric acid and is known to modulate cellular processes, including peroxisomal function. It has been recognized as an ACOX1 inhibitor, potentially influencing peroxisomal β-oxidation. | ||||||
Warfarin | 81-81-2 | sc-205888 sc-205888A | 1 g 10 g | $72.00 $162.00 | 7 | |
Warfarin, an anticoagulant, has been reported to inhibit ACOX1 activity. The exact mechanism of ACOX1 inhibition by Warfarin is not fully elucidated, but it may involve interference with peroxisomal function and fatty acid metabolism. Warfarin's impact on ACOX1 may result from alterations in the cellular lipid profile, affecting the availability of fatty acids for ACOX1-mediated β-oxidation processes within peroxisomes. | ||||||
Hexachlorophene | 70-30-4 | sc-211587 | 1 g | $247.00 | 1 | |
Hexachlorophene, an antibacterial agent, has been identified as an inhibitor of ACOX1. The precise mechanism of ACOX1 inhibition by Hexachlorophene is not fully understood, but it is likely related to alterations in peroxisomal function and fatty acid metabolism. Hexachlorophene's impact on ACOX1 may involve changes in the cellular lipid profile, affecting the availability of fatty acids for ACOX1-mediated β-oxidation processes within peroxisomes. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
Flufenamic Acid, a nonsteroidal anti-inflammatory drug, has been recognized as an inhibitor of ACOX1. The exact mechanism by which Flufenamic Acid inhibits ACOX1 is not fully elucidated but may involve interference with peroxisomal function and β-oxidation processes. The inhibition of ACOX1 by Flufenamic Acid may result from alterations in the cellular lipid profile, affecting the availability of fatty acids for ACOX1-mediated processes within peroxisomes. | ||||||
Cinnamic acid | 621-82-9 | sc-337631 | 1 g | $560.00 | ||
Cinnamic Acid is a natural compound identified as an inhibitor of ACOX1. The specific mechanism by which Cinnamic Acid inhibits ACOX1 is not fully understood, but it is likely related to alterations in peroxisomal function and fatty acid metabolism. Cinnamic Acid's impact on ACOX1 may involve changes in the cellular lipid profile, affecting the availability of fatty acids for ACOX1-mediated β-oxidation processes within peroxisomes. | ||||||