Molecular structure of WY 14643, CAS Number: 50892-23-4
WY 14643 (CAS 50892-23-4)
See product citations (7)
Alternate Names:
Pirinixic acid
Application:
WY 14643 is a highly potent PPARα agonist
CAS Number:
50892-23-4
Purity:
≥98%
Molecular Weight:
323.80
Molecular Formula:
C14H14ClN3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WY 14643 is a highly potent PPARalpha agonist. Peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma are hormone receptors that induce the gene acyl-Coa and modulate the peroxisomal beta oxidation of fatty acids. WY 14643 may act to inhibit TNF-alpha-induced VCAM-1, and reduce TNF-alpha and IL-1beta. Studies indicate that WY 14643 inhibits proliferation of trophoblast cells at lower concentrations than clofibric acid (sc-203000), and decreases the levels of S-100 β chain (S100B) protein.
WY 14643 (CAS 50892-23-4) References
- PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. | Marx, N., et al. 1999. Circulation. 99: 3125-31. PMID: 10377075
- Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | Murakami, K., et al. 1999. Biochem Biophys Res Commun. 260: 609-13. PMID: 10403814
- Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. | Ip, E., et al. 2004. Hepatology. 39: 1286-96. PMID: 15122757
- WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock. | Cuzzocrea, S., et al. 2004. Shock. 22: 340-6. PMID: 15377889
- Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. | Morimura, K., et al. 2006. Carcinogenesis. 27: 1074-80. PMID: 16377806
- Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643. | Collino, M., et al. 2006. Free Radic Biol Med. 41: 579-89. PMID: 16863991
- Peroxisome proliferator-activated receptors A link between endocrinology and nutrition? | Keller, H. and Wahli, W. 1993. Trends Endocrinol Metab. 4: 291-6. PMID: 18407172
- Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells. | Hashimoto, F., et al. 2009. Biol Pharm Bull. 32: 1278-82. PMID: 19571398
- PPAR-α Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial Fibroblasts via NF-kB Pathway. | Huang, D., et al. 2016. J Mol Neurosci. 59: 544-53. PMID: 27339772
- PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase. | Chen, X., et al. 2021. Free Radic Biol Med. 169: 283-293. PMID: 33892114
- Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. | Keller, H., et al. 1993. Proc Natl Acad Sci U S A. 90: 2160-4. PMID: 8384714
- Peroxisome proliferator-activated receptors: structures and function. | Tugwood, JD., et al. 1996. Ann N Y Acad Sci. 804: 252-65. PMID: 8993548
- Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. | Peters, JM., et al. 1997. Carcinogenesis. 18: 2029-33. PMID: 9395198
Inhibitor of:
4921528O07Rik, ABCD1, ABCG8, ACOX3, ACSM2A, ACSM5, Angptl2, Angptl7, C19orf12, EG226601, EHHADH, FACL6, GPD1, GPR6, HACL1, HkRP3, HSDL2, ILBP, iPLA2γ, Lipocalin-15, Lipocalin-9, Lipophilin B, LPAAT-ζ, METRNL, MondoA, NRIP2, PCBD1, PECR, Peroxin 11α, Peroxin 11β, Peroxin 13, Peroxin 19, Pex13p, Pex14p, PGC-1β, PHYHIPL, piccolo, PNPLA7, PRC, SCP2, SEC14L5, SLMO1, SPACR, T-FABP, TAF9B, THEM2, TMEM18, TUSC5, Usherin, and Vaspin.Activator of:
17β-HSD11, ABCD2, ABHD10, ABHD14A, Acaa1b, ACAD-8, ACAT-3, ACOT2, ACOT5, ACOT9, ACOX1, ACOX2, ACSBG2, ACSL1, ACSL6, ACSM2B, ACSM5, AKR1CL2, Angptl3, apoM, CD36, CDS2, Ces1d, CES3, CPTI-L, Cyp2c38, Cyp2c39, Cyp2c40, CYP4A, CYP4A1, CYP4A10, CYP4A11, CYP4A14, CYP4A22, CYP4A29, CYP4A30B, CYP4A32, Cyp4f39, Cyp4f40, CYP4V3, DAF-12, DECR2, FACL5, FATP-1, group IIF sPLA2, HNF-4γ, HNF-4B, L-FABP, LIPI, Lipin-2, Lipin-3, LPAAT-η, MCAD, MUP, OCTN3, ORP-10, PECI, PEPCK-M, Peroxin 12, Peroxin 16, Peroxin 3, Peroxin 5R, Peroxin 6, Peroxin 7, Peroxisome 26, Pex5p, PIP2, Pmp24, PPAR alpha, pUb-R, Pxmp2, Rtl1, RUNDC2A, SerpinA1e, Slfn3, SR-BI, StARD5, StARD9, TMEM195, TMEM41A, TRAP, TYSND1, and VPS8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WY 14643, 50 mg | sc-203314 | 50 mg | $136.00 |