Molecular structure of C75 (racemic), CAS Number: 191282-48-1
C75 (racemic) (CAS 191282-48-1)
See product citations (9)
Alternate Names:
C75 (racemic) is also known as (±)-C75.
Application:
C75 (racemic) is an inhibitor of fatty acid synthase, shown to exhibit irreversible slow-binding biphasic inactivation.
CAS Number:
191282-48-1
Purity:
>98%
Molecular Weight:
254.32
Molecular Formula:
C14H22O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C75 (racemic) is an inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. C75 (racemic) exhibits irreversible slow-binding biphasic inactivation of fatty acid synthase. C75 (racemic) downregulates neuropeptide Y and Agouti-related protein expression. It has been proposed that C75 (racemic) can activate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. C75 (racemic) shows significant antitumor activity in human breast cancer cells. Additionally, C75 (racemic) suppresses DNA replication and induces apoptosis. FAS inhibition by C75 (racemic) leads to a dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.
C75 (racemic) (CAS 191282-48-1) References
- C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. | Thupari, JN., et al. 2002. Proc Natl Acad Sci U S A. 99: 9498-502. PMID: 12060712
- C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. | Landree, LE., et al. 2004. J Biol Chem. 279: 3817-27. PMID: 14615481
- Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. | Thupari, JN., et al. 2004. Am J Physiol Endocrinol Metab. 287: E97-E104. PMID: 14736702
- C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. | Kim, EK., et al. 2004. J Biol Chem. 279: 19970-6. PMID: 15028725
- Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei. | Miller, I., et al. 2004. Neuroreport. 15: 925-9. PMID: 15073544
- C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure. | Tu, Y., et al. 2005. Endocrinology. 146: 486-93. PMID: 15498887
- Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats. | Aja, S., et al. 2006. Am J Physiol Regul Integr Comp Physiol. 291: R148-54. PMID: 16484442
- Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation. | Bentebibel, A., et al. 2006. Biochemistry. 45: 4339-50. PMID: 16584169
- C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight. | Mera, P., et al. 2009. Biochem Pharmacol. 77: 1084-95. PMID: 19094968
- The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice. | Pellinen, J. and Szentirmai, É. 2012. PLoS One. 7: e30651. PMID: 22348016
- Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. | Makowski, K., et al. 2013. Chirality. 25: 281-7. PMID: 23620264
- Fatty acid synthase inhibitor C75 ameliorates experimental colitis. | Matsuo, S., et al. 2014. Mol Med. 20: 1-9. PMID: 24306512
- Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. | Kim, YC., et al. 2019. Nat Chem Biol. 15: 907-916. PMID: 31427815
- The fatty acid synthase inhibitor C75 differentially affects the adipogenic differentiation of multipotent cells and preadipocytes. | Tseng, KY., et al. 2022. FEBS Lett. 596: 3191-3202. PMID: 35689495
Inhibitor of:
2900097C17Rik, 5330437I02Rik, 9130409I23Rik, AASDHPPT, ABHD15, ACCβ, ACOT6, ACOT9, ACOXL, ACSBG1, ACSBG2, ACSL6, ACSM2A, ACSM2B, ACSS1, ACSS3, ACSVL2, ACSVL6, AWAT1, CIDE-C, CPTI-L, CPTII, CRIP1, DES2, DGAT2L6, EG629667, ELOVL (ELOngation of Very Long chain fatty acids), FADS7_Degs1, FAR1, Fatty Acid Synthase, FPGS, FSBA, G6Pase-α, G6Pase-β, GFAT1, GLYATL3, GPAT2, GPR91, LENG4, LPGAT1, LRP2BP, MBOAT2, MDGI, Mecr, MLYCD, muscle FBPase, NFS1, PCYT2, Peroxin 19, PTRF, SCD3, SCD4, SKI-1, SPTLC1, THEM5, TMEM68, and ZDHHC5.Activator of:
ABHD14A, ACOX1, ACSM2B, EG329055, FADS2, FAS, NPC2, and PGS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C75 (racemic), 1 mg | sc-202511 | 1 mg | $71.00 | |||
C75 (racemic), 5 mg | sc-202511A | 5 mg | $202.00 | |||
C75 (racemic), 10 mg | sc-202511B | 10 mg | $284.00 |