ACAT-3 Activators
ACAT-3 Activators encompass a collection of chemical compounds that indirectly augment the functional activity of ACAT-3 through diverse signaling pathways and metabolic processes. Forskolin, by increasing cAMP, activates PKA, leading to an enhancement of ACAT-3's activity through phosphorylation, fine-tuning its role in lipid modification. Similarly, LY294002, as a PI3K inhibitor, and Fumonisin B1, through sphingolipid metabolism alteration, steer cellular signaling towards pathways that upregulate ACAT-3's activity. ACAT-3 Activators are an array of chemical entities that indirectly promote the functional activity of ACAT-3 by interacting with various cellular signaling and metabolic pathways. Forskolin, by elevating intracellular cAMP levels, indirectly triggers ACAT-3 activation through the subsequent PKA-mediated phosphorylation cascade, which is known to regulate proteins in lipid metabolism pathways where ACAT-3 operates. Sphingosine, as a bioactive lipid, activates protein kinase C, potentially enhancing ACAT-3's role in lipid processing by phosphorylation mechanisms. Oleoylethanolamide engages PPAR-alpha, modulating lipid metabolism and potentially enhancing ACAT-3 activity in fatty acid oxidation processes. Similarly, U73122 and Manumycin A modulate lipid signaling pathways, with U73122 inhibiting phospholipase C and Manumycin A targeting Ras farnesyltransferase, both potentially shifting the metabolic balance to favor ACAT-3's activity in lipid modification.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin acts by increasing intracellular cAMP levels, which enhances the activity of ACAT-3 by activating PKA that can phosphorylate ACAT-3, thus increasing its lipid-modifying activity. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $117.00 $469.00 | 18 | |
Fumonisin B1 inhibits ceramide synthase, leading to an accumulation of sphinganine. Sphinganine upregulation can increase ACAT-3 activity indirectly by altering the sphingolipid metabolism, in which ACAT-3 is a key player. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to the activation of ACAT-3 by reducing competitive downstream signaling, thereby allowing ACAT-3 pathways to be more active in lipid metabolism. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, indirectly enhancing ACAT-3 activity by promoting calcium-dependent phosphorylation processes that ACAT-3 may be involved in due to its role in lipid handling. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A | 50 mg 500 mg | $68.00 $357.00 | 11 | |
Clozapine, an antipsychotic, can indirectly enhance ACAT-3 by modulating the serotonergic system and altering lipid metabolism, which may upregulate ACAT-3's enzymatic activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, can act as a precursor for NAD+, which is essential in metabolic processes. Increased NAD+ levels can enhance ACAT-3 activity indirectly by providing more substrate for reactions that ACAT-3 catalyzes in lipid metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can enhance the activity of ACAT-3 by modulating lipid profiles and reducing inflammation, which can lead to a more favorable environment for ACAT-3's enzymatic action on lipid substrates. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1 channels, leading to increased intracellular calcium levels, which can enhance ACAT-3 activity by calmodulin-dependent kinase pathways, impacting lipid metabolism. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY-14643 is a PPARα agonist that can upregulate lipid metabolism pathways where ACAT-3 is potentially involved, leading to an indirect enhancement of ACAT-3's functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to influence lipid signaling pathways, indirectly enhancing ACAT-3 activity by modulating the cellular lipid environment that ACAT-3 regulates. | ||||||