Molecular structure of Fumonisin B1, CAS Number: 116355-83-0
Fumonisin B1 (CAS 116355-83-0)
See product citations (18)
Alternate Names:
Fumonisin B1 is also known as Macrofusine.
Application:
Fumonisin B1 is a serine and threonine phosphatase inhibitor.
CAS Number:
116355-83-0
Purity:
≥98%
Molecular Weight:
721.83
Molecular Formula:
C34H59NO15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Fumonisin B1 is a fungal metabolite found in Fusarium species of fungi, and it is extensively studied in agricultural research due to its occurrence in grains and its impact on crop quality and safety. Investigations into Fumonisin B1 include its biosynthesis by fungal pathogens and the genetic regulation of this process, which is important for developing strategies to reduce contamination in food supplies. Research on Fumonisin B1 also delves into its interactions with plant defense mechanisms, providing insights into the resilience of crops to fungal invasion. Additionally, the chemical′s role in disrupting sphingolipid metabolism is a focus in cellular studies, where it helps elucidate the complex pathways of lipid signaling and homeostasis. Environmental scientists examine the persistence and degradation of Fumonisin B1 in soil and water systems to better understand its ecological impact and to inform decontamination practices.
Fumonisin B1 (CAS 116355-83-0) References
- Fumonisins: fungal toxins that shed light on sphingolipid function. | Merrill, AH., et al. 1996. Trends Cell Biol. 6: 218-23. PMID: 15157459
- Continuous engagement of a self-specific activation receptor induces NK cell tolerance. | Tripathy, SK., et al. 2008. J Exp Med. 205: 1829-41. PMID: 18606857
- A review of the toxic effects and mechanisms of action of fumonisin B1. | Stockmann-Juvala, H. and Savolainen, K. 2008. Hum Exp Toxicol. 27: 799-809. PMID: 19244287
- Developmental Toxicity of Mycotoxin Fumonisin B₁ in Animal Embryogenesis: An Overview. | Lumsangkul, C., et al. 2019. Toxins (Basel). 11: PMID: 30781891
- Molecular mechanisms of fumonisin B1-induced toxicities and its applications in the mechanism-based interventions. | Liu, X., et al. 2019. Toxicon. 167: 1-5. PMID: 31173793
- Aptamer-based detection of fumonisin B1: A critical review. | Mirón-Mérida, VA., et al. 2021. Anal Chim Acta. 1160: 338395. PMID: 33894965
- Plant defence mechanisms against mycotoxin Fumonisin B1. | Iqbal, N., et al. 2021. Chem Biol Interact. 343: 109494. PMID: 33915161
- Research Progress on Fumonisin B1 Contamination and Toxicity: A Review. | Chen, J., et al. 2021. Molecules. 26: PMID: 34500671
- Sphingolipid synthesis inhibitor fumonisin B1 causes verticillium wilt in cotton. | Xu, F., et al. 2022. J Integr Plant Biol. 64: 836-842. PMID: 35238484
- Fumonisin B1 as a Tool to Explore Sphingolipid Roles in Arabidopsis Primary Root Development. | Zhao, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36361715
- Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | Merrill, AH., et al. 1993. J Biol Chem. 268: 27299-306. PMID: 8262970
- Inhibition of protein serine/threonine phosphatases by fumonisin B1, a mycotoxin. | Fukuda, H., et al. 1996. Biochem Biophys Res Commun. 220: 160-5. PMID: 8602837
- Activation of mitogen-activated protein kinase by the carcinogenic mycotoxin fumonisin B1. | Wattenberg, EV., et al. 1996. Biochem Biophys Res Commun. 227: 622-7. PMID: 8878562
Inhibitor of:
β-1,3-Gal-T6, β-1,4-Gal-T6, β-4-Gal-T4, β-Galactose Dehydrogenase S, β-ketoacyl synthase, β3Gn-T7, γ-FR, 9130409I23Rik, ABCA, AGAT, Alk-SMase, APHC, ASAH2B, ASAH3, ASAH3L, Blood Group H ab antigen, Blood Group H n, Ceramide Kinase, Ceramide Synthase (CERS; LASS), CERKL, CHPT1, claudin-15, CLDND1, DDHD1, DES2, DPPL2, EG629667, FADS7_Degs1, Forssman Antigen, GBGT1, GLTPD1, Gm438, GnT-IVH, GOLGA6L, iGb3, ILDR1, ISPD, LASS, LASS1, LASS2, LASS3, LASS4, LENG4, LOC388564, LPD lipase, MIS, N-SMase3, Olfr444, ORMDL2, PAM, PCDH19, PCYT2, PIG-A, PIG-S, PRR24, PSPH, PTPLB, SLC35A2, SLC35C1, SLC35D1, SLC35E3, Sphingomyelin Synthase 2, SPTLC1, SPTLC2, SPTSSA, St3Gal-II, STOP, SUSD3, UGP2, Unc18-3, ZDHHC11, ZDHHC11B, ZDHHC14, ZDHHC24, ZDHHC4, and ZDHHC6.Activator of:
9130409I23Rik, ACAT-3, Akt, ASAH2C, CCDC93, CDP2, D8S2298E, DPM1, EG629667, FAN, Ganglioside GD2, GD3 Synthase, GM3 Synthase, LAPTM4B, LASS2, LASS6, LRRC69, N-SMase, neutral ceramidase, O-Ac GD3, PGAP1, PIG-H, PIG-L, PIG-W, PIG-X, PPT2, PSS1, Ribosomal Protein L17, SEC14L5, SMPD5, SMPDL3B, SMS2, Sphingomyelin Synthase 1, Sphingomyelin Synthase 2, stefin A2l1, UGCG, Ypk2, ZDHHC11, ZDHHC14, ZDHHC15, ZDHHC23, ZDHHC25, and ZDHHC9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fumonisin B1, 1 mg | sc-201395 | 1 mg | $117.00 | |||
Fumonisin B1, 5 mg | sc-201395A | 5 mg | $469.00 |