ACAT-3 Activators
ACAT-3 Activators encompass a collection of chemical compounds that indirectly augment the functional activity of ACAT-3 through diverse signaling pathways and metabolic processes. Forskolin, by increasing cAMP, activates PKA, leading to an enhancement of ACAT-3's activity through phosphorylation, fine-tuning its role in lipid modification. Similarly, LY294002, as a PI3K inhibitor, and Fumonisin B1, through sphingolipid metabolism alteration, steer cellular signaling towards pathways that upregulate ACAT-3's activity. ACAT-3 Activators are an array of chemical entities that indirectly promote the functional activity of ACAT-3 by interacting with various cellular signaling and metabolic pathways. Forskolin, by elevating intracellular cAMP levels, indirectly triggers ACAT-3 activation through the subsequent PKA-mediated phosphorylation cascade, which is known to regulate proteins in lipid metabolism pathways where ACAT-3 operates. Sphingosine, as a bioactive lipid, activates protein kinase C, potentially enhancing ACAT-3's role in lipid processing by phosphorylation mechanisms. Oleoylethanolamide engages PPAR-alpha, modulating lipid metabolism and potentially enhancing ACAT-3 activity in fatty acid oxidation processes. Similarly, U73122 and Manumycin A modulate lipid signaling pathways, with U73122 inhibiting phospholipase C and Manumycin A targeting Ras farnesyltransferase, both potentially shifting the metabolic balance to favor ACAT-3's activity in lipid modification.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $200.00 $680.00 | 18 | |
Fumonisin B1 inhibits ceramide synthase, leading to an accumulation of sphinganine. Sphinganine upregulation can increase ACAT-3 activity indirectly by altering the sphingolipid metabolism, in which ACAT-3 is a key player. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to the activation of ACAT-3 by reducing competitive downstream signaling, thereby allowing ACAT-3 pathways to be more active in lipid metabolism. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, indirectly enhancing ACAT-3 activity by promoting calcium-dependent phosphorylation processes that ACAT-3 may be involved in due to its role in lipid handling. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A sc-200402B sc-200402C | 50 mg 500 mg 5 g 10 g | $69.00 $364.00 $2500.00 $4100.00 | 11 | |
Clozapine, an antipsychotic, can indirectly enhance ACAT-3 by modulating the serotonergic system and altering lipid metabolism, which may upregulate ACAT-3's enzymatic activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, can act as a precursor for NAD+, which is essential in metabolic processes. Increased NAD+ levels can enhance ACAT-3 activity indirectly by providing more substrate for reactions that ACAT-3 catalyzes in lipid metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can enhance the activity of ACAT-3 by modulating lipid profiles and reducing inflammation, which can lead to a more favorable environment for ACAT-3's enzymatic action on lipid substrates. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1 channels, leading to increased intracellular calcium levels, which can enhance ACAT-3 activity by calmodulin-dependent kinase pathways, impacting lipid metabolism. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643 is a PPARα agonist that can upregulate lipid metabolism pathways where ACAT-3 is potentially involved, leading to an indirect enhancement of ACAT-3's functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to influence lipid signaling pathways, indirectly enhancing ACAT-3 activity by modulating the cellular lipid environment that ACAT-3 regulates. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione, an antioxidant, can enhance ACAT-3 activity by maintaining a reductive environment, which is essential for the proper functioning of enzymes like ACAT-3 involved in lipid metabolism. | ||||||