Date published: 2025-11-21

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A cyclase Inhibitors

Adenylate cyclase (AC) inhibitors represent a class of compounds that specifically target and inhibit the activity of adenylate cyclase enzymes. Adenylate cyclase is an essential enzyme in the biochemical pathway responsible for converting adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP), a crucial second messenger in cellular signaling. cAMP plays a vital role in various cellular processes, including the regulation of metabolic pathways, gene expression, ion channel conductance, and cell proliferation. By inhibiting adenylate cyclase, AC inhibitors effectively reduce the intracellular levels of cAMP, thereby modulating the signaling pathways that rely on this molecule. The inhibition of adenylate cyclase can result in a cascade of downstream effects, influencing various biochemical and physiological processes at the cellular level. The mechanism of action of AC inhibitors can vary depending on the specific compound and its interaction with the adenylate cyclase isoforms. Adenylate cyclase exists in multiple isoforms, each with distinct regulatory mechanisms and tissue distribution. Some inhibitors may act by directly binding to the active site of the enzyme, thereby blocking the conversion of ATP to cAMP. Others might interfere with the regulatory proteins or subunits that modulate adenylate cyclase activity, such as G proteins or forskolin-binding sites. The specificity and potency of an AC inhibitor are influenced by its chemical structure and its ability to selectively target certain isoforms or regulatory elements of adenylate cyclase. The study and development of these inhibitors have provided valuable insights into the intricate regulation of cAMP signaling and have contributed to the broader understanding of cellular communication and signal transduction pathways.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Suramin sodium

129-46-4sc-507209
sc-507209F
sc-507209A
sc-507209B
sc-507209C
sc-507209D
sc-507209E
50 mg
100 mg
250 mg
1 g
10 g
25 g
50 g
$149.00
$210.00
$714.00
$2550.00
$10750.00
$21410.00
$40290.00
5
(1)

Suramin sodium (CAS 129-46-4) is a chemical compound that acts as an inhibitor of adenylate cyclase, an enzyme involved in cAMP production. It has been studied for its ability to modulate intracellular signaling pathways by blocking the conversion of ATP to cAMP, which is crucial for various cellular processes.

SQ 22536

17318-31-9sc-201572
sc-201572A
5 mg
25 mg
$93.00
$356.00
13
(1)

SQ 22536 (CAS 17318-31-9) is a chemical compound known for its role as an inhibitor of adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cAMP. By blocking this enzyme, SQ 22536 regulates cAMP levels, influencing various cellular processes and intracellular signaling pathways.

Vidarabine

5536-17-4sc-205881
sc-205881A
100 mg
500 mg
$52.00
$137.00
1
(1)

Vidarabine (CAS 5536-17-4) is a chemical compound that acts as an inhibitor of adenylate cyclase, an enzyme involved in the production of cyclic AMP (cAMP). By inhibiting adenylate cyclase, Vidarabine can modulate cAMP levels, affecting various cellular signaling processes and pathways.

NKH 477

138605-00-2sc-204130
sc-204130A
5 mg
50 mg
$219.00
$904.00
1
(0)

A water-soluble AC inhibitor that inhibits cAMP formation.

MDL-12,330A • HCl

40297-09-4sc-201574
sc-201574A
5 mg
25 mg
$71.00
$279.00
12
(1)

MDL-12,330A • HCl (CAS 40297-09-4) is a chemical compound known to act as an inhibitor of adenylate cyclase, an enzyme involved in the production of cyclic AMP (cAMP). By inhibiting adenylate cyclase, MDL-12,330A • HCl can modulate cAMP levels, potentially affecting various cellular signaling processes and pathways.

2′,3′-Dideoxyadenosine

4097-22-7sc-202406
sc-202406A
sc-202406B
1 mg
5 mg
25 mg
$41.00
$148.00
$398.00
7
(0)

2',3'-Dideoxyadenosine (CAS 4097-22-7) is a chemical compound known for its ability to inhibit adenylate cyclase, an enzyme involved in the production of cyclic AMP (cAMP). By interfering with adenylate cyclase activity, 2',3'-dideoxyadenosine may modulate cellular cAMP levels, potentially impacting various signaling pathways and cellular responses.

KH7

330676-02-3sc-252933
sc-252933A
sc-252933B
sc-252933C
5 mg
10 mg
25 mg
50 mg
$189.00
$253.00
$444.00
$797.00
(1)

KH7 (CAS 330676-02-3) is a chemical compound known for its inhibitory effects on adenylate cyclase, an enzyme involved in the production of cyclic AMP (cAMP). By interfering with adenylate cyclase activity, KH7 may regulate cAMP levels, potentially influencing various cellular signaling pathways and cellular responses.

2-Methylthio-ADP trisodium salt

475193-31-8sc-203464
10 mg
$822.00
5
(1)

2-Methylthio-ADP trisodium salt (CAS 475193-31-8) is a chemical compound known for its inhibitory effects on adenylate cyclase, an enzyme involved in the production of cyclic AMP (cAMP). By interfering with adenylate cyclase activity, 2-Methylthio-ADP trisodium salt may regulate cAMP levels, potentially influencing various cellular signaling pathways and cellular responses.

PD 81,723

132861-87-1sc-204837
sc-204837A
10 mg
50 mg
$155.00
$638.00
(0)

PD 81,723 (CAS 132861-87-1) is a chemical compound known for its inhibitory effects on adenylate cyclase, an enzyme involved in the production of cyclic AMP (cAMP). By interfering with adenylate cyclase activity, PD 81,723 may regulate cAMP levels, potentially influencing various cellular signaling pathways and cellular responses.

BPIPP

325746-94-9sc-203852
sc-203852A
10 mg
50 mg
$189.00
$797.00
1
(1)

BPIPP (CAS 325746-94-9) is a chemical compound known to act as an inhibitor of adenylate cyclase, an enzyme involved in the synthesis of cyclic AMP (cAMP). By blocking adenylate cyclase activity, BPIPP may modulate cAMP levels, potentially influencing various cellular processes and signaling pathways.