NKH 477 (CAS 138605-00-2)
See product citations (1)
QUICK LINKS
NKH 477 is a water-soluble forskolin derivative that has become a useful tool in various research studies. It is primarily used to activate adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP) inside cells. By increasing intracellular cAMP levels, NKH 477 allows researchers to investigate the signaling pathways that rely on this important second messenger, which is critical for understanding cellular responses to hormones and neurotransmitters. This activation provides insights into the regulation of heart muscle contraction and relaxation, making it a focal point in cardiovascular research. Additionally, NKH 477 is utilized in neuroscience studies to explore how cAMP-dependent signaling pathways affect neuronal function and plasticity. It also aids in the examination of cAMP′s role in regulating ion channel activity and is therefore a valuable compound in electrophysiological experiments.
NKH 477 (CAS 138605-00-2) References
- Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. | Liu, C., et al. 2022. Redox Biol. 52: 102292. PMID: 35325805
- Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism. | Zhao, J., et al. 2022. Bioorg Med Chem Lett. 71: 128807. PMID: 35605837
- Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle. | Mathes, S., et al. 2022. J Mol Med (Berl). 100: 1647-1658. PMID: 36178526
- Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist. | Zhao, J., et al. 2023. ACS Med Chem Lett. 14: 66-74. PMID: 36655128
- N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R). | Graziano, G., et al. 2023. Eur J Med Chem. 248: 115109. PMID: 36657299
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NKH 477, 5 mg | sc-204130 | 5 mg | $223.00 | |||
NKH 477, 50 mg | sc-204130A | 50 mg | $922.00 |